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Sofosbuvir

Molecular FormulaC₂₂H₂₉FN₃O₉P
Average mass529.453 Da
Monoisotopic mass529.162537 Da
ChemSpider ID26286922

- 6 of 6 defined stereocentres

More details:

Featured data source

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-4-fluoro-3-hydroxy-4-méthyltétrahydro-2-furanyl]méthoxy}(phénoxy)phosphoryl]amino}propanoate d'isopropyle [French] [ACD/IUPAC Name]

1190307-88-0 [RN]

Isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-4-fluoro-3-hydroxy-4-methyltetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate [ACD/IUPAC Name]

Isopropyl-(2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-4-fluor-3-hydroxy-4-methyltetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoat [German] [ACD/IUPAC Name]

Sofosbuvir [INN] [Wiki]

Sofosbuvir [Spanish] [INN]

Sofosbuvir [French] [INN]

Sofosbuvirum [Latin] [INN]

Sovaldi [Trade name]

Uridine, 2'-deoxy-2'-fluoro-2'-methyl-5'-O-[(S)-[[(1S)-1-methyl-2-(1-methylethoxy)-2-oxoethyl]amino]phenoxyphosphinyl]- [ACD/Index Name]

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WJ6CA3ZU8B

ψ-7977

(S)-2-{[(1R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(R)-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy]phenoxyphosphorylamino}propionic acid (S)-isopropyl ester

(S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

1868135-06-1 [RN]

GI 7977

GI-7977

GI-7977|ψ 7977|Sovaldi®

GS 7977

GS 7977;ψ 7977;sofosbuvir

GS-7977

isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate

MFCD18782704

MFCD26523124

propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate

propan-2-yl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate

S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)- (phenoxy)phosphorylamino)propanoate

Sofosbuvir (ψ-7977, GS-7977)

Sofosbuvir D6

sofosbuvirum

Sovaldi®

UNII:WJ6CA3ZU8B

UNII-WJ6CA3ZU8B

ψ 7977

софосбувир [Russian]

سوفوسبوفير [Arabic]

索磷布韦 [Chinese]

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

9665 [DBID]

Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Experimental Physico-chemical Properties

Experimental Solubility:

Miscellaneous

Safety:

J05AX15 Wikidata Q2502747

Chemical Class:

Bio Activity:

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density:	1.4±0.1 g/cm³
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction:	1.573
Molar Refractivity:	123.5±0.4 cm³
#H bond acceptors:	12
#H bond donors:	3
#Freely Rotating Bonds:	11
#Rule of 5 Violations:	2

ACD/LogP:	1.62
ACD/LogD (pH 5.5):	0.72
ACD/BCF (pH 5.5):	2.07
ACD/KOC (pH 5.5):	58.64
ACD/LogD (pH 7.4):	0.71
ACD/BCF (pH 7.4):	2.05
ACD/KOC (pH 7.4):	58.01
Polar Surface Area:	163 Å²
Polarizability:	48.9±0.5 10^-24cm³
Surface Tension:	58.7±5.0 dyne/cm
Molar Volume:	374.6±5.0 cm³

Click to predict properties on the Chemicalize site

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Sofosbuvir

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