ChemSpider 2D Image | NVP-BVU972 | C20H16N6


  • Molecular FormulaC20H16N6
  • Average mass340.381 Da
  • Monoisotopic mass340.143646 Da
  • ChemSpider ID26325538

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1185763-69-2 [RN]
6-{[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}chinolin [German] [ACD/IUPAC Name]
6-{[6-(1-Méthyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]méthyl}quinoléine [French] [ACD/IUPAC Name]
6-{[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline [ACD/IUPAC Name]
Quinoline, 6-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]- [ACD/Index Name]
[1185763-69-2] [RN]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Target Organs:

      c-Met inhibitor TargetMol T2680
    • Bio Activity:

      c-Met TargetMol T2680
      c-Met/HGFR MedChem Express HY-15456
      NVP-BVU972 is a selective and potent Met inhibitor (IC50 = 14 nM). MedChem Express, HY-15456
      NVP-BVU972 is a selective and potent Met inhibitor (IC50 = 14 nM). Antitumor agents.;IC50 value: 14 nM [1];Target: MetNVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM. NVP-BVU972 also suppresses constitutive MET phosphorylation in GTL-16 cells or HGF-stimulated MET phosphorylation in A549 cells with IC50 values of 7.3 nM and 22 nM, respectively. NVP-BVU972 potently prevents the growth of the MET gene amplified cell lines GTL-16, MKN-45 and EBC-1 with IC50 values of 66 nM, 82 nM and 32 nM, respectively. In line with their high frequency in the NVP-BVU972 screen, Y1230 and D1228 mutations give rise to dramatic shifts in the measured IC50 values for NVP-BVU972 in BaF3 cell line. Resistance triggered by V1155L is more limited to NVP-BVU972. A dose-dependent reduction in TPR-MET phosphorylation when applying NVP-BVU972 to BaF3 cells expressing wild-type TPR-MET. MedChem Express HY-15456
      Protein Tyrosine Kinase/RTK MedChem Express HY-15456
      Protein Tyrosine Kinase/RTK; MedChem Express HY-15456
      Tyrosine Kinase/Adaptors TargetMol T2680

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.745
Molar Refractivity: 101.9±0.5 cm3
#H bond acceptors: 6
#H bond donors: 0
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 2.12
ACD/LogD (pH 5.5): 2.52
ACD/BCF (pH 5.5): 44.69
ACD/KOC (pH 5.5): 476.85
ACD/LogD (pH 7.4): 2.68
ACD/BCF (pH 7.4): 63.71
ACD/KOC (pH 7.4): 679.83
Polar Surface Area: 61 Å2
Polarizability: 40.4±0.5 10-24cm3
Surface Tension: 57.5±7.0 dyne/cm
Molar Volume: 251.4±7.0 cm3

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