ChemSpider 2D Image | Alectinib hydrochloride | C30H35ClN4O2

Alectinib hydrochloride

  • Molecular FormulaC30H35ClN4O2
  • Average mass519.078 Da
  • Monoisotopic mass518.244873 Da
  • ChemSpider ID26332606

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Alectinib hydrochloride
1256589-74-8 [RN]
5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-, hydrochloride (1:1) [ACD/Index Name]
9-Ethyl-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-3-carbonitrilhydrochlorid (1:1) [German] [ACD/IUPAC Name]
9-Ethyl-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloride (1:1) [ACD/IUPAC Name]
9-Éthyl-6,6-diméthyl-8-[4-(4-morpholinyl)-1-pipéridinyl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
UNII:P9YY73LO6J
[1256589-74-8] [RN]
1256589-74-8 (HCl)
2-Isopropoxyphenol [ACD/IUPAC Name]
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A hydrochloride obtained by combining alectinib with one molar equivalent of hydrochloric acid. Used for the treatment of patients with anaplastic lymphoma kinase-positive, metastatic non-small cell l ung cancer. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:62268, CHEBI:62268

    • Bio Activity:

      ALK MedChem Express HY-13011A
      CH5424802 Hcl (AF 802 Hcl; Alectinib Hcl) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. MedChem Express http://www.medchemexpress.com/lacosamide-racemate.html
      CH5424802 Hcl (AF 802 Hcl; Alectinib Hcl) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. ;IC50 value: 1.9 nM [1] ;Target: ALK;In vitro: The dissociation constant (KD) value of CH5424802 for ALK in an ATP-competitive manner is 2.4 nM. CH5424802 has substantial inhibitory potency against both native ALK and L1196M with Ki of 0.83 nM and 1.56 nM, respectively. CH5424802 prevents autophosphorylation of ALK in NCI-H2228 NSCLC cells expressing EML4-ALK. CH5424802 also suppresses the phosphorylation of STAT3 and AKT, but not of ERK1/2. CH5424802 completely inhibits the phosphorylation of STAT3 at Tyr705. CH5424802 is preferentially efficacious against NCI-H2228 cells expressing EML4-ALK, but not ALK fusion-negative NSCLC cell lines, including HCC827 cells (EGFR exon 19 deletion), A549 cells (KRAS mutant), or NCI-H522 cells (EGFR wild-type, KRAS wild-type, and ALK wild-type) in monolayer culture. CH5424802 elicits an apoptotic marker?caspase-3/7-like activatio MedChem Express HY-13011A
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13011A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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