ChemSpider 2D Image | GSK2334470 | C25H34N8O

GSK2334470

  • Molecular FormulaC25H34N8O
  • Average mass462.591 Da
  • Monoisotopic mass462.285553 Da
  • ChemSpider ID26346147

  • defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidincarboxamid [German] [ACD/IUPAC Name]
(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide [ACD/IUPAC Name]
(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(méthylamino)-4-pyrimidinyl]-N-cyclohexyl-6-méthyl-3-pipéridinecarboxamide [French] [ACD/IUPAC Name]
(3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide
1227911-45-6 [RN]
3-Piperidinecarboxamide, 1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-, (3S,6R)- [ACD/Index Name]
GSK2334470
MFCD21608525
(3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-N-cyclohexyl-6-methylpiperidine-3-carboxamide
[1227911-45-6] [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes only under agreement from GlaxoSmithKline Tocris Bioscience 4143

    • Bio Activity:

      Enzymes Tocris Bioscience 4143
      GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.; IC50 value: 10 nM [1]; Target: PDK1; in vitro: GSK2334470 inhibits PDK1 from activating full-length Akt1 in the presence of PtdIns(3,4,5)P3-containing lipid vesicles or a mutant of Akt1 lacking the PH domain (?PH-Akt1) with IC50 of ~10 nM. MedChem Express HY-14981
      Highly potent, selective PDK1 inhibitor Tocris Bioscience 4143
      Highly potent, selective PDPK1 (PDK1) inhibitor Tocris Bioscience 4143
      Kinases Tocris Bioscience 4143
      PDK1 Tocris Bioscience 4143
      PDK-1 MedChem Express HY-14981
      Phosphoinositide-dependent Kinase 1 Tocris Bioscience 4143
      PI3K/Akt/mTOR MedChem Express HY-14981
      PI3K/Akt/mTOR; MedChem Express HY-14981
      Potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation a nd subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice. Tocris Bioscience 4143
      Potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice. Tocris Bioscience 4143
      Potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC50 ~ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice. Tocris Bioscience 4143

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.667
Molar Refractivity: 131.9±0.4 cm3
#H bond acceptors: 9
#H bond donors: 5
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 1
ACD/LogP: 2.31
ACD/LogD (pH 5.5): 0.63
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 4.34
ACD/LogD (pH 7.4): 1.91
ACD/BCF (pH 7.4): 9.10
ACD/KOC (pH 7.4): 82.41
Polar Surface Area: 125 Å2
Polarizability: 52.3±0.5 10-24cm3
Surface Tension: 73.9±5.0 dyne/cm
Molar Volume: 354.3±5.0 cm3

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