ChemSpider 2D Image | SAR131675 | C18H22N4O4

SAR131675

  • Molecular FormulaC18H22N4O4
  • Average mass358.392 Da
  • Monoisotopic mass358.164093 Da
  • ChemSpider ID28424132

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo- [ACD/Index Name]
1092539-44-0 [RN]
1433953-83-3 [RN]
2-Amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butin-1-yl]-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-carboxamid [German] [ACD/IUPAC Name]
2-Amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide [ACD/IUPAC Name]
2-Amino-1-éthyl-7-[(3R)-3-hydroxy-4-méthoxy-3-méthyl-1-butyn-1-yl]-N-méthyl-4-oxo-1,4-dihydro-1,8-naphtyridine-3-carboxamide [French] [ACD/IUPAC Name]
2-amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl]-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
2-amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl]-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide
SAR131675
(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Protein Tyrosine Kinase/RTK; MedChem Express HY-15458
      SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc. MedChem Express
      VEGFR MedChem Express HY-15458

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 592.2±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.8 mmHg at 25°C
Enthalpy of Vaporization: 92.9±3.0 kJ/mol
Flash Point: 312.0±30.1 °C
Index of Refraction: 1.626
Molar Refractivity: 94.8±0.4 cm3
#H bond acceptors: 8
#H bond donors: 4
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: -0.61
ACD/LogD (pH 5.5): 0.08
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 26.36
ACD/LogD (pH 7.4): 0.08
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 26.48
Polar Surface Area: 118 Å2
Polarizability: 37.6±0.5 10-24cm3
Surface Tension: 69.2±5.0 dyne/cm
Molar Volume: 267.9±5.0 cm3

Click to predict properties on the Chemicalize site


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