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ChemSpider 2D Image | 3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine | C16H16N6


  • Molecular FormulaC16H16N6
  • Average mass292.338 Da
  • Monoisotopic mass292.143646 Da
  • ChemSpider ID28542287

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amin [German] [ACD/IUPAC Name]
3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine [ACD/IUPAC Name]
3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine [French] [ACD/IUPAC Name]
Imidazo[1,2-b]pyridazin-6-amine, 3-(1H-indazol-5-yl)-N-propyl- [ACD/Index Name]
1333377-65-3 [RN]
CHR 6494
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-15217
      Cell Cycle/DNA Damage; MedChem Express HY-15217
      CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation. MedChem Express, HY-15217
      CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation. ;IC50 Value: N/A;Target: Haspin KinaseCHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity. MedChem Express HY-15217
      Haspin Kinase MedChem Express HY-15217

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.747
Molar Refractivity: 85.1±0.5 cm3
#H bond acceptors: 6
#H bond donors: 2
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 2.48
ACD/LogD (pH 5.5): 2.00
ACD/BCF (pH 5.5): 17.62
ACD/KOC (pH 5.5): 243.10
ACD/LogD (pH 7.4): 2.16
ACD/BCF (pH 7.4): 25.79
ACD/KOC (pH 7.4): 355.76
Polar Surface Area: 71 Å2
Polarizability: 33.7±0.5 10-24cm3
Surface Tension: 58.0±7.0 dyne/cm
Molar Volume: 209.6±7.0 cm3

Click to predict properties on the Chemicalize site