ChemSpider 2D Image | Wnt-C59 | C25H21N3O

Wnt-C59

  • Molecular FormulaC25H21N3O
  • Average mass379.454 Da
  • Monoisotopic mass379.168457 Da
  • ChemSpider ID28654675

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1243243-89-1 [RN]
2-[4-(2-Methyl-4-pyridinyl)phenyl]-N-[4-(3-pyridinyl)phenyl]acetamid [German] [ACD/IUPAC Name]
2-[4-(2-Methyl-4-pyridinyl)phenyl]-N-[4-(3-pyridinyl)phenyl]acetamide [ACD/IUPAC Name]
2-[4-(2-Méthyl-4-pyridinyl)phényl]-N-[4-(3-pyridinyl)phényl]acétamide [French] [ACD/IUPAC Name]
2-[4-(2-Methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide
Benzeneacetamide, 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]- [ACD/Index Name]
Wnt-C59
[1243243-89-1] [RN]
1-Ethyl-5-methyl-1H-pyrazole-4-carbaldehyde [ACD/IUPAC Name]
2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

C59 [DBID]
CCRIS 4693 [DBID]
PubChem Substance ID 329825761 [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Wnt/beta-catenin inhibitor TargetMol T2242

    • Bio Activity:

      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB3155
      Cell process/Stem cells/Differentiation Hello Bio HB3155
      Enzymes Tocris Bioscience 5148
      Enzymes/Transferase/PORCN Hello Bio HB3155
      Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 tran sgenic mice and downregulates Wnt/?-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailab le. Tocris Bioscience 5148
      Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/?-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable. Tocris Bioscience 5148
      Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/beta-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable. Tocris Bioscience 5148
      Highly potent PORCN inhibitor Tocris Bioscience 5148
      Highly potent PORCN inhibitor. Induces iPSC cardiomyocytes differentiation. Hello Bio HB3155
      PORCN Tocris Bioscience 5148
      Porcupine MedChem Express HY-15659
      Porcupine TargetMol T2242
      Porcupine Wnt MedChem Express HY-15659
      Potent, cell permeable PORCN inhibitor (IC<sub>50</sub> = 74 pM). >100-fold more potent than IWP1. Potently inhibits Wnt/?-catenin signaling. Also induces induced pluripotent stem cell (iPSC) cardiomyocyte differentiation when used in combination with CHIR 99021. Hello Bio HB3155
      Potent, cell permeable PORCN inhibitor (IC<sub>50</sub> = 74 pM). >100-fold more potent than IWP1. Potently inhibits Wnt/žì-catenin signaling. Also induces induced pluripotent stem cell (iPSC) cardiomyocyte differentiation when used in combination with CHIR 99021. Hello Bio HB3155
      Stem Cell TargetMol T2242
      Transferases Tocris Bioscience 5148
      Wnt/Hedgehog/Notch MedChem Express HY-15659
      Wnt/Hedgehog/Notch; MedChem Express HY-15659
      Wnt-C59 (C59) is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. MedChem Express http://www.medchemexpress.com/gsk-j1-lithium-salt.html, HY-15659

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 628.3±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.8 mmHg at 25°C
Enthalpy of Vaporization: 93.0±3.0 kJ/mol
Flash Point: 333.8±31.5 °C
Index of Refraction: 1.648
Molar Refractivity: 115.2±0.3 cm3
#H bond acceptors: 4
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 4.19
ACD/LogD (pH 5.5): 3.45
ACD/BCF (pH 5.5): 150.67
ACD/KOC (pH 5.5): 708.51
ACD/LogD (pH 7.4): 4.30
ACD/BCF (pH 7.4): 1071.73
ACD/KOC (pH 7.4): 5039.59
Polar Surface Area: 55 Å2
Polarizability: 45.7±0.5 10-24cm3
Surface Tension: 53.5±3.0 dyne/cm
Molar Volume: 316.5±3.0 cm3

Click to predict properties on the Chemicalize site


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