ChemSpider 2D Image | BLZ-945 | C20H22N4O3S

BLZ-945

  • Molecular FormulaC20H22N4O3S
  • Average mass398.479 Da
  • Monoisotopic mass398.141266 Da
  • ChemSpider ID29362221

  • defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-Pyridinecarboxamide, 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl- [ACD/Index Name]
4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methyl-2-pyridincarboxamid [German] [ACD/IUPAC Name]
4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methyl-2-pyridinecarboxamide [ACD/IUPAC Name]
4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-méthyl-2-pyridinecarboxamide [French] [ACD/IUPAC Name]
4-[(2-{[(1R,2R)-2-hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methylpyridine-2-carboxamide
7W3V82OQ0P
953769-46-5 [RN]
BLZ-945
[953769-46-5] [RN]
4-((2-(((1R,2R)-2-hydroxycyclohexyl)amino)benzo[d]thiazol-6-yl)oxy)-N-methylpicolinamide
More...
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio [HB4634]
      BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; MedChem Express http://www.medchemexpress.com/Cyantraniliprole.html
      BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases.; IC50 value: 1 nM [1]; Target: CSF-1R inhibitor; in vitro: Treatment of bone marrow-derived macrophages (BMDMs) with BLZ945 inhibited CSF-1-dependent proliferation (EC50=67nM), and decreased CSF-1R phosphorylation, similar to CSF-1R antibody blockade. MedChem Express HY-12768
      BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases.;IC50 value: 1 nM [1];Target: CSF-1R inhibitor;In vitro: Treatment of bone marrow-derived macrophages (BMDMs) with BLZ945 inhibited CSF-1-dependent proliferation (EC50=67nM), and decreased CSF-1R phosphorylation, similar to CSF-1R antibody blockade. BLZ945 also reduced viability of CRL-2467 microglia, Ink4a/Arf/BMDMs (PDG genetic background), and NOD/SCID BMDMs. Importantly, BLZ945 treatment in culture did not affect proliferation of any PDG-derived tumor[1].;In vivo: BLZ945-treated TAMs retained CSF-1R expression in vivo, and there were no significant differences compared to vehicle-treated PDG gliomas. four human lines responded to BLZ945 in vivo, showing a clear histological response, and significantly reduced tumor growth and invasion [1]. BLZ945 decreases primary mammary tumor growth but does not affect lung metastatic tumor burden in MM MedChem Express HY-12768
      c-Fms MedChem Express HY-12768
      Orally active, potent and selective colony stimulating factor 1 receptor (CSF-1R) inhibitor. More than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and platelet-derived growth factor receptor beta (PDGFRbeta). Selective against more than 200 additional kinases. Hello Bio [HB4634]
      Potent, selective colony stimulating factor 1 receptor (CSF-1R) inhibitor Hello Bio [HB4634]
      Protein Tyrosine Kinase/RTK MedChem Express HY-12768
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12768
      Receptors & Transporters/Enzyme-linked (Catalytic)/RTK/Colony stimulating factor 1 receptor Hello Bio [HB4634]

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.693
Molar Refractivity: 111.0±0.3 cm3
#H bond acceptors: 7
#H bond donors: 3
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 2.50
ACD/LogD (pH 5.5): 2.21
ACD/BCF (pH 5.5): 27.97
ACD/KOC (pH 5.5): 377.25
ACD/LogD (pH 7.4): 2.21
ACD/BCF (pH 7.4): 28.08
ACD/KOC (pH 7.4): 378.71
Polar Surface Area: 125 Å2
Polarizability: 44.0±0.5 10-24cm3
Surface Tension: 64.5±3.0 dyne/cm
Molar Volume: 289.4±3.0 cm3

Click to predict properties on the Chemicalize site


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