ChemSpider 2D Image | TIC10 | C24H26N4O

TIC10

  • Molecular FormulaC24H26N4O
  • Average mass386.489 Da
  • Monoisotopic mass386.210663 Da
  • ChemSpider ID30904994

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1616632-77-9 [RN]
7-Benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-on [German] [ACD/IUPAC Name]
7-Benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one [ACD/IUPAC Name]
7-Benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one [French] [ACD/IUPAC Name]
9U35A31JAI
Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-4-[(2-methylphenyl)methyl]-7-(phenylmethyl)- [ACD/Index Name]
ONC-201
TIC10
[1616632-77-9] [RN]
1616632-77-9 (free base)
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Akt ERK MedChem Express HY-15615A
      ERK MedChem Express HY-15615A
      MAPK MedChem Express HY-15615A
      MAPK; PI3K/Akt/mTOR; MedChem Express HY-15615A
      TIC10(ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. MedChem Express
      TIC10(ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.; IC50 Value: ; Target: Akt; ERK; TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. MedChem Express HY-15615A
      TIC10(ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.;IC50 Value: ;Target: Akt; ERK;TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL [1].http://onlinelibrary.wiley.com/doi/10.1002/anie.201402133/abstract MedChem Express HY-15615A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 559.7±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.5 mmHg at 25°C
Enthalpy of Vaporization: 84.2±3.0 kJ/mol
Flash Point: 292.3±32.9 °C
Index of Refraction: 1.672
Molar Refractivity: 116.0±0.5 cm3
#H bond acceptors: 5
#H bond donors: 0
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 3.14
ACD/LogD (pH 5.5): 1.89
ACD/BCF (pH 5.5): 8.43
ACD/KOC (pH 5.5): 74.80
ACD/LogD (pH 7.4): 2.98
ACD/BCF (pH 7.4): 104.54
ACD/KOC (pH 7.4): 927.96
Polar Surface Area: 39 Å2
Polarizability: 46.0±0.5 10-24cm3
Surface Tension: 50.9±7.0 dyne/cm
Molar Volume: 309.7±7.0 cm3

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