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ChemSpider 2D Image | (1S)-1-[(1R,2S,4R)-Bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(1-piperidinyl)-1-propanol | C21H29NO

(1S)-1-[(1R,2S,4R)-Bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(1-piperidinyl)-1-propanol

  • Molecular FormulaC21H29NO
  • Average mass311.461 Da
  • Monoisotopic mass311.224915 Da
  • ChemSpider ID31132159
  • defined stereocentres - 3 of 4 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(1S)-1-[(1R,2S,4R)-Bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(1-piperidinyl)-1-propanol [German] [ACD/IUPAC Name]
(1S)-1-[(1R,2S,4R)-Bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(1-piperidinyl)-1-propanol [ACD/IUPAC Name]
(1S)-1-[(1R,2S,4R)-Bicyclo[2.2.1]hept-5-én-2-yl]-1-phényl-3-(1-pipéridinyl)-1-propanol [French] [ACD/IUPAC Name]
1-Piperidinepropanol, α-[(1R,2S,4R)-bicyclo[2.2.1]hept-5-en-2-yl]-α-phenyl-, (αS)- [ACD/Index Name]
514-65-8 [RN]
Akineton [Wiki]
Akineton;KL 373

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

KL 373 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Biperiden(KL 373) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker. MedChem Express
      Biperiden(KL 373) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.; Target: M1 receptors; Biperiden is an antiparkinsonian agent of the anticholinergic type. MedChem Express HY-13204A
      Biperiden(KL 373) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.;Target: M1 receptorsBiperiden is an antiparkinsonian agent of the anticholinergic type. It is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic)[1]. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate. It also has a prominent central blocking effect on M1 receptors [2].Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg),caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty, whereas biperiden and procyclidine did not [3].Clinical indications: parkinsonismFDA Approved Date: MedChem Express HY-13204A
      GPCR/G protein MedChem Express HY-13204A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-13204A
      mAChR MedChem Express HY-13204A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.1±0.1 g/cm3
Boiling Point: 462.1±40.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.2 mmHg at 25°C
Enthalpy of Vaporization: 76.2±3.0 kJ/mol
Flash Point: 224.5±26.0 °C
Index of Refraction: 1.583
Molar Refractivity: 94.1±0.3 cm3
#H bond acceptors: 2
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 4.01
ACD/LogD (pH 5.5): 1.17
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 4.38
ACD/LogD (pH 7.4): 2.35
ACD/BCF (pH 7.4): 12.92
ACD/KOC (pH 7.4): 65.07
Polar Surface Area: 23 Å2
Polarizability: 37.3±0.5 10-24cm3
Surface Tension: 46.9±3.0 dyne/cm
Molar Volume: 281.7±3.0 cm3

Click to predict properties on the Chemicalize site






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