ChemSpider 2D Image | AZ 7371 | C18H21N5O3

AZ 7371

  • Molecular FormulaC18H21N5O3
  • Average mass355.391 Da
  • Monoisotopic mass355.164429 Da
  • ChemSpider ID31132722

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1494675-86-3 [RN]
1H-Pyrrolo[3,2-b]pyridine-3-carboxamide, N-(2-hydroxyethyl)-1-[(6-methoxy-5-methyl-4-pyrimidinyl)methyl]-6-methyl- [ACD/Index Name]
AZ 7371
N-(2-Hydroxyethyl)-1-[(6-methoxy-5-methyl-4-pyrimidinyl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridin-3-carboxamid [German] [ACD/IUPAC Name]
N-(2-Hydroxyethyl)-1-[(6-methoxy-5-methyl-4-pyrimidinyl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide [ACD/IUPAC Name]
N-(2-Hydroxyéthyl)-1-[(6-méthoxy-5-méthyl-4-pyrimidinyl)méthyl]-6-méthyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide [French] [ACD/IUPAC Name]
N-(2-Hydroxyethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
N-(2-hydroxyethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]-6-methylpyrrolo[3,2-b]pyridine-3-carboxamide
AZ7371
DprE1-IN-1
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      DprE1-IN-1 is a potent DprE1 inhibitor, with ic50 of 10 nM, also inhibits PDE6, with IC50 of 6 uM.; IC50 value: 10 nM [1]; Target: DprE1; in vitro: DprE1-IN-1 demonstrats efficacy in a rodent model of tuberculosis, making it promising for further development.[1]; in vivo: The pharmacokinetic profile of DprE1-IN-1 as a representative of the series in mice, rats, and dogs was determined after i.v. MedChem Express HY-19750
      Others MedChem Express HY-19750

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 691.6±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.3 mmHg at 25°C
Enthalpy of Vaporization: 106.4±3.0 kJ/mol
Flash Point: 372.1±31.5 °C
Index of Refraction: 1.650
Molar Refractivity: 96.6±0.5 cm3
#H bond acceptors: 8
#H bond donors: 2
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 1.37
ACD/LogD (pH 5.5): 1.10
ACD/BCF (pH 5.5): 3.64
ACD/KOC (pH 5.5): 78.16
ACD/LogD (pH 7.4): 1.27
ACD/BCF (pH 7.4): 5.43
ACD/KOC (pH 7.4): 116.67
Polar Surface Area: 102 Å2
Polarizability: 38.3±0.5 10-24cm3
Surface Tension: 50.5±7.0 dyne/cm
Molar Volume: 264.8±7.0 cm3

Click to predict properties on the Chemicalize site


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