ChemSpider 2D Image | defactinib hydrochloride | C20H22ClF3N8O3S

defactinib hydrochloride

  • Molecular FormulaC20H22ClF3N8O3S
  • Average mass546.954 Da
  • Monoisotopic mass546.117615 Da
  • ChemSpider ID32695162

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1073160-26-5 [RN]
Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-, hydrochloride (1:1) [ACD/Index Name]
defactinib hydrochloride [USAN]
L2S469LM49
N-Methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]-2-pyrazinyl}methyl)amino]-5-(trifluormethyl)-2-pyrimidinyl}amino)benzamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
N-Methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]-2-pyrazinyl}methyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl}amino)benzamide hydrochloride (1:1) [ACD/IUPAC Name]
N-Méthyl-4-({4-[({3-[méthyl(méthylsulfonyl)amino]-2-pyrazinyl}méthyl)amino]-5-(trifluorométhyl)-2-pyrimidinyl}amino)benzamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
N-methyl-4-({4-[({3-[methyl(methylsulfonyl)amino]pyrazin-2-yl}methyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl}amino)benzamide monohydrochloride
N-METHYL-4-{[4-({[3-(N-METHYLMETHANESULFONAMIDO)PYRAZIN-2-YL]METHYL}AMINO)-5-(TRIFLUOROMETHYL)PYRIMIDIN-2-YL]AMINO}BENZAMIDE HYDROCHLORIDE
VS-6063
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Defactinib Hcl (VS-6063; PF-04554878) is a potent FAK phosphorylation inhibitor; overcomes YB-1?mediated paclitaxel; resistance by an AKT-dependent pathway.; IC50 value:; Target: FAK inhibitor; VS-6063 inhibited FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. MedChem Express HY-12289A
      Defactinib Hcl (VS-6063; PF-04554878) is a potent FAK phosphorylation inhibitor; overcomes YB-1?mediated paclitaxelresistance by an AKT-dependent pathway.;IC50 value:;Target: FAK inhibitorVS-6063 inhibited FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. The combination of VS-6063 and paclitaxel markedly decreased proliferation and increased apoptosis, which resulted in 92.7% to 97.9% reductions in tumor weight. RPPA data showed that VS-6063 reduced levels of AKT and YB-1 in taxane-resistant cell lines. FAK inhibition enhanced chemosensitivity in taxane-resistant cells by decreasing YB-1 phosphorylation and subsequently CD44 in an AKT-dependent manner. MedChem Express HY-12289A
      Defactinib Hcl (VS-6063; PF-04554878) is a potent FAK phosphorylation inhibitor; overcomes YB-1–mediated paclitaxel MedChem Express
      FAK MedChem Express HY-12289A
      Protein Tyrosine Kinase/RTK MedChem Express HY-12289A
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12289A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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