ChemSpider 2D Image | Osimertinib mesylate | C29H37N7O5S

Osimertinib mesylate

  • Molecular FormulaC29H37N7O5S
  • Average mass595.713 Da
  • Monoisotopic mass595.257690 Da
  • ChemSpider ID32743638

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1421373-66-1 [RN]
2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-, methanesulfonate (1:1) [ACD/Index Name]
Acide méthanesulfonique - N-(2-{[2-(diméthylamino)éthyl](méthyl)amino}-4-méthoxy-5-{[4-(1-méthyl-1H-indol-3-yl)-2-pyrimidinyl]amino}phényl)acrylamide (1:1) [French] [ACD/IUPAC Name]
Methansulfonsäure --N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}phenyl)acrylamid (1:1) [German] [ACD/IUPAC Name]
N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}phenyl)acrylamide methanesulfonate (1:1) [ACD/IUPAC Name]
N-(2-{[2-(DIMETHYLAMINO)ETHYL](METHYL)AMINO}-4-METHOXY-5-{[4-(1-METHYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL]AMINO}PHENYL)PROP-2-ENAMIDE; METHANESULFONIC ACID
Osimertinib mesylate [USAN]
RDL94R2A16
Tagrisso [Trade name]
UNII-RDL94R2A16
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

AZD9291 mesylate [DBID]
AZD-9291mesylate [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A methanesulfonate (mesylate) salt prepared from equimolar amounts of osimertinib and methanesulfonic acid. It is used for treatment of EGFR T790M mutation positive non-small cell lung cancer. ChEBI CHEBI:90948
      A methanesulfonate (mesylate) salt prepared from equimolar amounts of osimertinib and methanesulfonic acid. Used for treatment of EGFR T790M mutation positive non-small cell lung cancer. ChEBI CHEBI:90948

    • Bio Activity:

      AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM). MedChem Express http://www.medchemexpress.com/a-419259.html, HY-15772A
      AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM). ;IC50 value: 12.92 nM(Exon 19 deletion EGFR); 11.44 nM(L858R/T790M EGFR) [1];Target: L858R/T790M EGFR; Exon 19 deletion EGFRAZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines.Patent: WO 2013014448 MedChem Express HY-15772A
      EGFR MedChem Express HY-15772A
      JAK/STAT Signaling MedChem Express HY-15772A
      JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; MedChem Express HY-15772A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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