ChemSpider 2D Image | GS967 | C14H7F6N3O

GS967

  • Molecular FormulaC14H7F6N3O
  • Average mass347.215 Da
  • Monoisotopic mass347.049316 Da
  • ChemSpider ID35308207

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,2,4-Triazolo[4,3-a]pyridine, 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)- [ACD/Index Name]
1262618-39-2 [RN]
6-[4-(Trifluormethoxy)phenyl]-3-(trifluormethyl)[1,2,4]triazolo[4,3-a]pyridin [German] [ACD/IUPAC Name]
6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
6-[4-(Trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine [ACD/IUPAC Name]
6-[4-(Trifluorométhoxy)phényl]-3-(trifluorométhyl)[1,2,4]triazolo[4,3-a]pyridine [French] [ACD/IUPAC Name]
GS967
(6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine)
6-(4-(Trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Sodium Channel inhibitor TargetMol T2049

    • Bio Activity:

      GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa); inhibits ATX-II-induced late I(Na) in ventricular myocytes and isolated hearts with IC(50) values of 0.13 and 0.21 ?M, respectively.; IC50 value:; Target: late INa inhibitor; in vitro: Reduction of peak I(Na) by GS967 was minimal at a holding potential of -120 mV but increased at -80 mV. MedChem Express HY-12593
      late INa inhibitor TargetMol T2049
      Membrane Tranporter/Ion Channel MedChem Express HY-12593
      Membrane Tranporter/Ion Channel; MedChem Express HY-12593
      Membrane Transporter/Ion Channel TargetMol T2049
      Sodium Channel MedChem Express HY-12593

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.539
Molar Refractivity: 71.2±0.5 cm3
#H bond acceptors: 4
#H bond donors: 0
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 4.56
ACD/LogD (pH 5.5): 3.40
ACD/BCF (pH 5.5): 225.29
ACD/KOC (pH 5.5): 1681.49
ACD/LogD (pH 7.4): 3.40
ACD/BCF (pH 7.4): 225.29
ACD/KOC (pH 7.4): 1681.49
Polar Surface Area: 39 Å2
Polarizability: 28.2±0.5 10-24cm3
Surface Tension: 35.3±7.0 dyne/cm
Molar Volume: 227.3±7.0 cm3

Click to predict properties on the Chemicalize site


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