ChemSpider 2D Image | GDC-0917 | C29H36N6O4S

GDC-0917

  • Molecular FormulaC29H36N6O4S
  • Average mass564.699 Da
  • Monoisotopic mass564.251892 Da
  • ChemSpider ID35308299

  • defined stereocentres - 3 of 3 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-{(2S)-2-Cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[2-(1,3-oxazol-2-yl)-4-phenyl-1,3-thiazol-5-yl]-L-prolinamid [German] [ACD/IUPAC Name]
1-{(2S)-2-Cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[2-(1,3-oxazol-2-yl)-4-phenyl-1,3-thiazol-5-yl]-L-prolinamide [ACD/IUPAC Name]
1-{(2S)-2-Cyclohexyl-2-[(N-méthyl-L-alanyl)amino]acétyl}-N-[2-(1,3-oxazol-2-yl)-4-phényl-1,3-thiazol-5-yl]-L-prolinamide [French] [ACD/IUPAC Name]
1446182-94-0 [RN]
2-Pyrrolidinecarboxamide, 1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-N-[2-(2-oxazolyl)-4-phenyl-5-thiazolyl]-, (2S)- [ACD/Index Name]
GDC-0917
KWH46ZDG32
(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-[2-(1,3-oxazol-2-yl)-4-phenyl-1,3-thiazol-5-yl]pyrrolidine-2-carboxamide
2-Propyn-1-ylcyclopropane [ACD/IUPAC Name]
CUDC 427
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Apoptosis MedChem Express HY-15835
      Apoptosis; MedChem Express HY-15835
      CUDC-427(GDC-0917) is a small-molecule peptide mimetic of SMAC/DIABLO; directly antagonize inhibitors of apoptosis proteins (IAPs). MedChem Express http://www.medchemexpress.com/bromosporine.html, HY-15835
      CUDC-427(GDC-0917) is a small-molecule peptide mimetic of SMAC/DIABLO; directly antagonize inhibitors of apoptosis proteins (IAPs). ;IC50 value:;Target: IAPs inhibitorCUDC-427 is currently developed by Curis, Inc, who licensed from Genentech. CUDC-417 is an orally bioavailable small molecule that triggers tumor cell apoptosis by selectively antagonizing IAP proteins. CUDC-427 was designed to mimic the endogenous IAP antagonist, second mitochondria-derived activator of caspases/direct IAP-binding protein (Smac/DIABLO) that is released into the cytoplasm in response to pro-apoptotic stimuli. CUDC-427 has demonstrated single-agent and combination therapy anti-tumor activity in mouse xenograft tumor models when administered orally, and IND-enabling safety studies have shown it to be well tolerated when dosed daily by oral administration, potentially enabling sustained target inhibition. MedChem Express HY-15835
      IAP MedChem Express HY-15835

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.608
Molar Refractivity: 152.3±0.3 cm3
#H bond acceptors: 10
#H bond donors: 3
#Freely Rotating Bonds: 9
#Rule of 5 Violations: 2
ACD/LogP: 2.83
ACD/LogD (pH 5.5): 0.22
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 2.81
ACD/LogD (pH 7.4): 1.92
ACD/BCF (pH 7.4): 12.21
ACD/KOC (pH 7.4): 141.40
Polar Surface Area: 158 Å2
Polarizability: 60.4±0.5 10-24cm3
Surface Tension: 58.7±3.0 dyne/cm
Molar Volume: 440.6±3.0 cm3

Click to predict properties on the Chemicalize site


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