ChemSpider 2D Image | CPI-360 | C25H31N3O4

CPI-360

  • Molecular FormulaC25H31N3O4
  • Average mass437.531 Da
  • Monoisotopic mass437.231445 Da
  • ChemSpider ID35308305

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1802175-06-9 [RN]
1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]- [ACD/Index Name]
CPI-360
N-[(4-Methoxy-6-methyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-1H-indol-3-carboxamid [German] [ACD/IUPAC Name]
N-[(4-Methoxy-6-methyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-2-methyl-1-[(1R)-1-(tetrahydro-2H-pyran-4-yl)ethyl]-1H-indole-3-carboxamide [ACD/IUPAC Name]
N-[(4-Méthoxy-6-méthyl-2-oxo-1,2-dihydro-3-pyridinyl)méthyl]-2-méthyl-1-[(1R)-1-(tétrahydro-2H-pyran-4-yl)éthyl]-1H-indole-3-carboxamide [French] [ACD/IUPAC Name]
N-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-(oxan-4-yl)ethyl]-1H-indole-3-carboxamide
N-[(4-METHOXY-6-METHYL-2-OXO-1H-PYRIDIN-3-YL)METHYL]-2-METHYL-1-[(1R)-1-(OXAN-4-YL)ETHYL]INDOLE-3-CARBOXAMIDE
(R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide
CPI 360
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-15955
      Cell Cycle/DNA Damage; MedChem Express HY-15955
      CPI-360 is a compound in design and preparation of wew palladium precatalysts for C-C and C-N cross-coupling reactions. MedChem Express http://www.medchemexpress.com/6-FAM-SE.html
      CPI-360 is a potent, selective EZH2inhibitor with IC50 of 0.5 nM and 2.5 nM nM for wt EZH2 and Y641N EZH2, respectively.; IC50 value: 0.5 nM, 2.5 nM; Target: EZH2; in vitro: CPI-360 functions on the basis of S-adenosyl-Lmethionine; (SAM)-competition, inhibits EZH1 about 100-fold less and shows exquisite selectivity across a large panel of histone lysine and arginine, and DNA methyltransferases. MedChem Express HY-15955
      CPI-360 is a potent, selective EZH2inhibitor with IC50 of 0.5 nM and 2.5 nM nM for wt EZH2 and Y641N EZH2, respectively.;IC50 value: 0.5 nM, 2.5 nM;Target: EZH2;In vitro: CPI-360 functions on the basis of S-adenosyl-Lmethionine(SAM)-competition, inhibits EZH1 about 100-fold less and shows exquisite selectivity across a large panel of histone lysine and arginine, and DNA methyltransferases. CPI-360 potently reduced global H3K27me3 and H3K27me2 levels in a dosedependent manner. CPI-360 effectively suppressed heavy H3K27me3 incorporation in KARPAS-422 cells without affecting total histone turnover. CPI-360 treatment causes time-dependent transcriptional changes in germinal center B cell-like diffuse large B cell lymphoma.;In vivo: Twice daily, subcutaneous administration of 200 mg/kg ofCPI-360 reduced tumor growth (TGI 44%) of KARPAS-422 xenografts in mice without affecting body weight or causing any overt adverse effects. CPI-360 completely inhibits EZH2 catalytic activity, sinc MedChem Express HY-15955
      EZH2 MedChem Express HY-15955

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 712.2±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.3 mmHg at 25°C
Enthalpy of Vaporization: 104.1±3.0 kJ/mol
Flash Point: 384.5±32.9 °C
Index of Refraction: 1.621
Molar Refractivity: 121.4±0.5 cm3
#H bond acceptors: 7
#H bond donors: 2
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 2.20
ACD/LogD (pH 5.5): 2.33
ACD/BCF (pH 5.5): 34.51
ACD/KOC (pH 5.5): 439.00
ACD/LogD (pH 7.4): 2.33
ACD/BCF (pH 7.4): 34.50
ACD/KOC (pH 7.4): 438.89
Polar Surface Area: 82 Å2
Polarizability: 48.1±0.5 10-24cm3
Surface Tension: 45.1±7.0 dyne/cm
Molar Volume: 344.9±7.0 cm3

Click to predict properties on the Chemicalize site


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