ChemSpider 2D Image | Gabexate mesilate | C17H27N3O7S

Gabexate mesilate

  • Molecular FormulaC17H27N3O7S
  • Average mass417.477 Da
  • Monoisotopic mass417.156982 Da
  • ChemSpider ID38378

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxyl]benzoic acid ethyl ester mesylate salt
56974-61-9 [RN]
Acide méthanesulfonique - 4-[(6-carbamimidamidohexanoyl)oxy]benzoate d'éthyle (1:1) [French] [ACD/IUPAC Name]
Benzoic acid, 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester, methanesulfonate (1:1) [ACD/Index Name]
benzoic acid, 4-[[6-[(diaminomethylene)amino]-1-oxohexyl]oxy]-, ethyl ester, methanesulfonate (1:1)
DG2800800
Ethyl 4-({6-[(diaminomethylene)amino]hexanoyl}oxy)benzoate methanesulfonate (1:1)
ethyl 4-({6-[(diaminomethylidene)amino]hexanoyl}oxy)benzoate methanesulfonate (1:1)
Ethyl 4-[(6-carbamimidamidohexanoyl)oxy]benzoate methanesulfonate (1:1) [ACD/IUPAC Name]
ETHYL 4-[(6-CARBAMIMIDAMIDOHEXANOYL)OXY]BENZOATE; METHANESULFONIC ACID
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

E3Q07L0649 [DBID]
D01672 [DBID]
NCGC00017121-01 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Serine Protease inhibitor TargetMol T0372

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 1798
      Factor Xa MedChem Express HY-B0385
      Factor Xa Proteasome MedChem Express HY-B0385
      Gabexate Mesylate is a Factor X inhibitor; serine protease inhibitor . MedChem Express
      Gabexate Mesylate is a Factor X inhibitor; serine protease inhibitor .; Target: Factor X; Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases that is therapeutically used in the treatment of pancreatitis and disseminated intravascular coagulation and as a regional anticoagulant for hemodialysis. MedChem Express HY-B0385
      Gabexate Mesylate is a Factor X inhibitor; serine protease inhibitor .;Target: Factor XGabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases that is therapeutically used in the treatment of pancreatitis and disseminated intravascular coagulation and as a regional anticoagulant for hemodialysis. Values of the inhibition constant (K(i)) for gabexate mesylate binding to human and bovine tryptase were 3.4 x 10(-9) M and 1.8 x 10(-7) M (at pH 7.4 and 37.0 degrees ), respectively. Gabexate mesylate inhibited the fibrinogenolytic activity of human tryptase [1]. Gabexate Mesylate decreased the TNFalpha production of LPS-stimulated monocytes as shown by the inhibition of mRNA expression and increased the IL-10 production of LPS-stimulated monocytes. Gabexate Mesylate also suppressed the NFkappaB activity of LPS-stimulated monocytes. Inhibitory effect of Gabexate Mesylate on the TNFalpha production of activated human monocytes is mediated by the suppress MedChem Express HY-B0385
      Metabolism/Protease MedChem Express HY-B0385
      Metabolism/Protease; MedChem Express HY-B0385
      Peptide Receptors Tocris Bioscience 1798
      Protease-Activated Receptors Tocris Bioscience 1798
      Proteases/Proteasome TargetMol T0372
      Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin Tocris Bioscience 1798
      Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 ?M respectively). Antithrombotic in vitro and in vivo. Also inhibits LPS-induc ed TNF-? production, probably by inhibiting NF-?B and AP-1 activation. Tocris Bioscience 1798
      Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 ?M respectively). Antithrombotic in vitro and in vivo. Also inhibits LPS-induced TNF-? production, probably by inhibiting NF-?B and AP-1 activation. Tocris Bioscience 1798
      Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 muM respectively). Antithrombotic in vitro and in vivo. Also inhibits LPS-induced TNF-alpha production, probably by inhibiting NF-kappaB and AP-1 activation. Tocris Bioscience 1798
      Trypsin-like serine proteinases TargetMol T0372

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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