ChemSpider 2D Image | TCMDC-123920 | C17H17ClF6N2O

TCMDC-123920

  • Molecular FormulaC17H17ClF6N2O
  • Average mass414.773 Da
  • Monoisotopic mass414.093353 Da
  • ChemSpider ID390111

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[2,8-Bis(trifluormethyl)-4-chinolinyl](2-piperidinyl)methanolhydrochlorid (1:1) [German] [ACD/IUPAC Name]
[2,8-Bis(trifluorométhyl)-4-quinoléinyl](2-pipéridinyl)méthanol, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
[2,8-Bis(trifluoromethyl)-4-quinolinyl](2-piperidinyl)methanol hydrochloride (1:1) [ACD/IUPAC Name]
[2,8-Bis(trifluoromethyl)quinolin-4-yl](piperidin-2-yl)methanol hydrochloride (1:1)
2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidinium chloride
4-Quinolinemethanol, α-2-piperidinyl-2,8-bis(trifluoromethyl)-, hydrochloride (1:1) [ACD/Index Name]
mefloquine hydrochloride
MEFLOQUINE HYDROCHLORIDE, (+)
TCMDC-123920
(R*,R*)-(2,8-BIS-TRIFLUOROMETHYL-(QUINOLIN-4-YL))-PIPERIDIN-2-YL-METHANOL HCL
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

326VC85GV6 [DBID]
5Y9L3636O3 [DBID]
D00831 [DBID]
LS-142001 [DBID]
Prestwick_538 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Hemozoin synthesis inhibitor TargetMol T0860

    • Bio Activity:

      <p>Cx36 and Cx50 gap channel blocker (IC<sub>50</sub> values are 0.3 and 1.1 &micro;M, respectively). Other gap junctions (e.g. Cx43, Cx32, and Cx26) are only affected at concentrations 10-100 fold higher. In neocortical slices, mefloquine blocks gap junctional coupling between interneurons with minimal nonspecific actions.</p> <p>Also shows antimalarial action. Inhibits the 80S ribosome of <i>Plasmodium falciparum</i> to block protein synthesis.</p> <p>Additionally shows antischistosomal and antiviral actions and has recently been investigated as part of COVID-19 compound repurposing.</p> Hello Bio HB9555
      hemozoin TargetMol T0860
      Microbiology & Virology TargetMol T0860

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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