ChemSpider 2D Image | delavirdine mesilate | C23H32N6O6S2

delavirdine mesilate

  • Molecular FormulaC23H32N6O6S2
  • Average mass552.667 Da
  • Monoisotopic mass552.182495 Da
  • ChemSpider ID390125

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(3-(Isopropylamino)-2-pyridyl)-4-((5-methanesulfonamidoindol-2-yl)carbonyl)piperazine monomethanesulfonate
147221-93-0 [RN]
Acide méthanesulfonique - N-[2-({4-[3-(isopropylamino)-2-pyridinyl]-1-pipérazinyl}carbonyl)-1H-indol-5-yl]méthanesulfonamide (1:1) [French] [ACD/IUPAC Name]
acide méthanesulfonique - N-{2-[(4-{3-[(1-méthyléthyl)amino]pyridin-2-yl}pipérazin-1-yl)carbonyl]-1H-indol-5-yl}méthanesulfonamide (1:1)
delavirdine mesilate [INN]
DELAVIRDINE MESYLATE [USAN]
Delavirdine monomethanesulfonate
Methanesulfonamide, N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-, methanesulfonate (1:1) [ACD/Index Name]
Methansulfonsäure --N-[2-({4-[3-(isopropylamino)-2-pyridinyl]-1-piperazinyl}carbonyl)-1H-indol-5-yl]methansulfonamid (1:1) [German] [ACD/IUPAC Name]
Methansulfonsäure--N-{2-[(4-{3-[(1-methylethyl)amino]pyridin-2-yl}piperazin-1-yl)carbonyl]-1H-indol-5-yl}methansulfonamid(1:1)
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

421105KRQE [DBID]
C08087 [DBID]
CCRIS 4693 [DBID]
D00895 [DBID]
DRG 0166 [DBID]
U 90152 [DBID]
UNII:421105KRQE [DBID]
UNII-421105KRQE [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Viiv. Tocris Bioscience 4149

    • Chemical Class:

      The monomethanesulfonic acid salt of delavirdine, a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection. ChEBI CHEBI:4379

    • Bio Activity:

      Anti-infection MedChem Express HY-10571A
      Anti-infection; MedChem Express HY-10571A
      Delavirdine(U 90152) mesylate is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI).; IC50 Value: 0.26 uM (Recombinant HIV-1 RT) [1]; Target: HIV-1 reverse transcriptase; NNRTI; in vitro: U-90152 [1-(5-methanesulfonamido-1H-indol-2-yl-carbonyl)-4-[3-(1-methyl eth yl-amino)pyridinyl]piperazine], which inhibited recombinant HIV-1 RT at a 50% inhibitory concentration (IC50) of 0.26 microM (compared with IC50s of > 440 microM for DNA polymerases alpha and delta). MedChem Express HY-10571A
      Delavirdine(U 90152) mesylate is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI).;IC50 Value: 0.26 uM (Recombinant HIV-1 RT) [1];Target: HIV-1 reverse transcriptase; NNRTI;In vitro: U-90152 [1-(5-methanesulfonamido-1H-indol-2-yl-carbonyl)-4-[3-(1-methyl eth yl-amino)pyridinyl]piperazine], which inhibited recombinant HIV-1 RT at a 50% inhibitory concentration (IC50) of 0.26 microM (compared with IC50s of > 440 microM for DNA polymerases alpha and delta). U-90152 blocked the replication in peripheral blood lymphocytes of 25 primary HIV-1 isolates, including variants that were highly resistant to 3'-azido-2',3'-dideoxythymidine (AZT) or 2',3'-dideoxyinosine, with a mean 50% effective dose of 0.066 +/- 0.137 microM. U-90152 had low cellular cytotoxicity, causing less than 8% reduction in peripheral blood lymphocyte viability at 100 microM. In experiments assessing inhibition of the spread of HIV-1IIIB in cell cultures, U-90152 was much more effective than AZT. When appr MedChem Express HY-10571A
      Enzymes Tocris Bioscience 4149
      HIV MedChem Express HY-10571A
      HIV NNRTIs MedChem Express HY-10571A
      Non-nucleoside reverse transcriptase inhibitor Tocris Bioscience 4149
      Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and > 550 ?M for HIV-1 reverse transcriptase, DNA polymerase ? and DNA polymerase ?). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active. Tocris Bioscience 4149
      Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 ?M for HIV-1 reverse transcriptase, DNA polymerase ? and DNA polymerase ?). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active. Tocris Bioscience 4149
      Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 muM for HIV-1 reverse transcriptase, DNA polymerase alpha and DNA polymerase delta). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active. Tocris Bioscience 4149
      Polymerases Tocris Bioscience 4149
      RNA/DNA Polymerase Tocris Bioscience 4149

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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