ChemSpider 2D Image | ginkgetin | C32H22O10

ginkgetin

  • Molecular FormulaC32H22O10
  • Average mass566.511 Da
  • Monoisotopic mass566.121277 Da
  • ChemSpider ID4436579

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

481-46-9 [RN]
4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-hydroxyphenyl)-
4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)- [ACD/Index Name]
5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-chromen-4-on [German] [ACD/IUPAC Name]
5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-chromen-4-one [ACD/IUPAC Name]
5,7-Dihydroxy-8-[5-(5-hydroxy-7-méthoxy-4-oxo-4H-chromén-2-yl)-2-méthoxyphényl]-2-(4-hydroxyphényl)-4H-chromén-4-one [French] [ACD/IUPAC Name]
ginkgetin
[481-46-9] [RN]
3''',8-Biflavone, 4',5,5'',7-tetrahydroxy-4''',7''-dimethoxy-
4''',5,5'',7''-tetrahydroxy-4',7-dimethoxy-(3'->8'')-biflavone
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

AIDS210280 [DBID]
AIDS-210280 [DBID]
C10048 [DBID]
KBio2_002469 [DBID]
KBio2_005037 [DBID]
KBio2_007605 [DBID]
KBio3_002594 [DBID]
KBioGR_001959 [DBID]
KBioSS_002476 [DBID]
SPBio_000207 [DBID]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from <ital>Ginkgo biloba</ital> and <ital>Dioon</ital>, it exhibits anti-HSV-1, antineoplastic and inhibitory activ ities towards arachidonate 5-lipoxygenase and cyclooxygenase 2. ChEBI CHEBI:5353
      A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activ; ities towards arachidona te 5-lipoxygenase and cyclooxygenase 2. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5353
      A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2. ChEBI CHEBI:5353

    • Bio Activity:

      Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L; effects of anti-inflammation and anticancer have been reported. MedChem Express
      Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L; effects of anti-inflammation and anticancer have been reported.; IC50 value:; Target:; in vitro: Ginkgetin inhibits COX-2 dependent phases of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC(50) values of 0.75 microM. MedChem Express HY-N0889
      Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L; effects of anti-inflammation and anticancer have been reported.;IC50 value:;Target:;In vitro: Ginkgetin inhibits COX-2 dependent phases of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC(50) values of 0.75 microM. Ginkgetin consistently inhibited the production of leukotriene C(4) (LTC(4)) in a dose dependent manner, with an IC(50) value of 0.33 microM. Ginkgetin also inhibited degranulation reaction in a dose dependent manner, with an IC(50) value of 6.52 microM [1]. Ginkgetin inhibited both inducible and constitutively activated STAT3 and blocked the nuclear translocation of p-STAT3 in DU-145 prostate cancer cells. Furthermore, ginkgetin selectively inhibited the growth of prostate tumor cells stimulated with activated STAT3. Ginkgetin induced STAT3 dephosphorylation at Try705 and inhibited its localization to the nucleus, leading MedChem Express HY-N0889
      Others MedChem Express HY-N0889
  • Gas Chromatography

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 863.7±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.3 mmHg at 25°C
Enthalpy of Vaporization: 129.8±3.0 kJ/mol
Flash Point: 287.2±27.8 °C
Index of Refraction: 1.714
Molar Refractivity: 147.6±0.3 cm3
#H bond acceptors: 10
#H bond donors: 4
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 2
ACD/LogP: 4.45
ACD/LogD (pH 5.5): 4.38
ACD/BCF (pH 5.5): 1112.01
ACD/KOC (pH 5.5): 4604.04
ACD/LogD (pH 7.4): 1.71
ACD/BCF (pH 7.4): 2.38
ACD/KOC (pH 7.4): 9.87
Polar Surface Area: 152 Å2
Polarizability: 58.5±0.5 10-24cm3
Surface Tension: 72.2±3.0 dyne/cm
Molar Volume: 376.1±3.0 cm3

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