ChemSpider 2D Image | PF06273340 | C23H22ClN7O3

PF06273340

  • Molecular FormulaC23H22ClN7O3
  • Average mass479.919 Da
  • Monoisotopic mass479.147278 Da
  • ChemSpider ID48244961

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1402438-74-7 [RN]
2-Pyridineacetamide, N-[5-[[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro- [ACD/Index Name]
N-(5-{[2-Amino-7-(1-hydroxy-2-methyl-2-propanyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}-3-pyridinyl)-2-(5-chlor-2-pyridinyl)acetamid [German] [ACD/IUPAC Name]
N-(5-{[2-Amino-7-(1-hydroxy-2-methyl-2-propanyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}-3-pyridinyl)-2-(5-chloro-2-pyridinyl)acetamide [ACD/IUPAC Name]
N-(5-{[2-Amino-7-(1-hydroxy-2-méthyl-2-propanyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}-3-pyridinyl)-2-(5-chloro-2-pyridinyl)acétamide [French] [ACD/IUPAC Name]
N-(5-{[2-Amino-7-(2-hydroxy-1 ,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5- yl]carbonyl}pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide
N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide
N-{5-[2-Amino-7-(1-Hydroxy-2-Methylpropan-2-Yl)-7h-Pyrrolo[2,3-D]pyrimidine-5-Carbonyl]pyridin-3-Yl}-2-(5-Chloropyridin-2-Yl)acetamide
N-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide
PF 06273340
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

I136775ABW [DBID]
UNII:I136775ABW [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 6115

    • Bio Activity:

      Enzyme-Linked Receptors Tocris Bioscience 6115
      Potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable. Tocris Bioscience 6115
      Potent and selective pan-Trk inhibitor; peripherally restricted Tocris Bioscience 6115
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 6115
      Trk Receptors Tocris Bioscience 6115

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.711
Molar Refractivity: 126.8±0.5 cm3
#H bond acceptors: 10
#H bond donors: 4
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 1
ACD/LogP: 0.92
ACD/LogD (pH 5.5): 1.22
ACD/BCF (pH 5.5): 4.70
ACD/KOC (pH 5.5): 97.92
ACD/LogD (pH 7.4): 1.34
ACD/BCF (pH 7.4): 6.08
ACD/KOC (pH 7.4): 126.59
Polar Surface Area: 149 Å2
Polarizability: 50.3±0.5 10-24cm3
Surface Tension: 61.7±7.0 dyne/cm
Molar Volume: 324.3±7.0 cm3

Click to predict properties on the Chemicalize site


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