ChemSpider 2D Image | Lipaxan | C24H25FNNaO4

Lipaxan

  • Molecular FormulaC24H25FNNaO4
  • Average mass433.448 Da
  • Monoisotopic mass433.166534 Da
  • ChemSpider ID4925638

  • Charge - Charge

    Double-bond stereo - Double-bond stereo

    defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(+)-3R,5S-FLUVASTATIN SODIUM SALT
(3R,5S)-fluvastatin sodium
(3R,5S,6E)-7-[3-(4-fluorophényl)-1-(1-méthyléthyl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-énoate de sodium
(3R,5S,6E)-7-[3-(4-Fluorophényl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy-6-hepténoate de sodium [French] [ACD/IUPAC Name]
155229-75-7 [RN]
6-heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, monosodium salt, (3R,5S,6E)-
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, sodium salt, (3R,5S,6E)- (1:1) [ACD/Index Name]
93957-55-2 [RN]
fluindostatin
Fluvastatin sodium
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 6848 [DBID]
D00892 [DBID]
Prestwick_1032 [DBID]
Sri 62320 [DBID]
Sri-62320 [DBID]
UNII-PYF7O1FV7F [DBID]
XU-620 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      An organic sodium salt resulting from the replacement of the proton from the carboxy group of (3<stereo>R</stereo>,5<stereo>S</stereo>)-fluvastatin by a sodium ion. ChEBI CHEBI:77602
      An organic sodium salt resulting from the replacement of the proton from the carboxy group of (3R,5S)-fluvastatin by a sodium ion. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:77602, CHEBI:77602
      Reductases Tocris Bioscience 3309

    • Bio Activity:

      Fluvastatin sodium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), used to treat hypercholesterolemia and to prevent cardiovascular disease. MedChem Express
      Fluvastatin sodium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), used to treat hypercholesterolemia and to prevent cardiovascular disease.; Target: HMGCR ; Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. MedChem Express HY-14664A
      Fluvastatin sodium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), used to treat hypercholesterolemia and to prevent cardiovascular disease.;Target: HMGCR Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. ;In the presence of Fluvastatin, HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. MedChem Express HY-14664A
      HMG-CoA Reductase (HMGCR) MedChem Express HY-14664A
      HMG-CoA reductase inhibitor Tocris Bioscience 3309
      Metabolism/Protease MedChem Express HY-14664A
      Metabolism/Protease; MedChem Express HY-14664A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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