ChemSpider 2D Image | GR-43175 | C18H27N3O6S

GR-43175

  • Molecular FormulaC18H27N3O6S
  • Average mass413.488 Da
  • Monoisotopic mass413.162048 Da
  • ChemSpider ID53920

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide butanedioate
1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide butanedioate (1:1)
1-{3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide succinate
1-{3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide succinate (1:1)
1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide; butanedioic acid
103628-48-4 [RN]
1H-Indole-5-methanesulfonamide, 3-[2-(dimethylamino)ethyl]-N-methyl-, butanedioate (1:1) [ACD/Index Name]
3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate
acide butanedioïque - 1-{3-[2-(diméthylamino)éthyl]-1H-indol-5-yl}-N-méthylméthanesulfonamide (1:1)
Acide succinique - 1-{3-[2-(diméthylamino)éthyl]-1H-indol-5-yl}-N-méthylméthanesulfonamide (1:1) [French] [ACD/IUPAC Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

J8BDZ68989 [DBID]
D00676 [DBID]
GR 43175 [DBID]
SN-308 [DBID]
UNII:J8BDZ68989 [DBID]
UNII-J8BDZ68989 [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      5-HT Receptor agonist TargetMol T0203

    • Chemical Class:

      A succinate salt obtained by reaction of sumatriptan with one equivalent of succinic acid. Selective agonist for a vascular 5-HT<smallsub>1</smallsub> receptor subtype (probably a member of the 5-HT<s mallsub>1D</smallsub> family). Used for the acute treatment of migraine with or without aura in adults. ChEBI CHEBI:64359
      A succinate salt obtained by reaction of sumatriptan with one equivalent of succinic acid. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used for th e acute treatment of migraine with or without aura in adults. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:64359, CHEBI:64359

    • Bio Activity:

      5-HT Receptor MedChem Express HY-B0121
      5-HT Receptor TargetMol T0203
      5-HT Receptors Tocris Bioscience 3586
      5-HT<sub>1D</sub>, 5-HT<sub>1B</sub> and 5-HT<sub>1A</sub> receptor agonist Hello Bio HB1769
      5-HT1 receptor agonist (Ki values are 17, 27 and 100 nM at 5-HT1D, 5-HT1B and 5-HT1A receptors respectively). Antimigraine agent. Tocris Bioscience 3586
      5-HT1 Receptors Tocris Bioscience 3586
      5-HT1A/1B/1D receptor agonist Tocris Bioscience 3586
      5-HT1A/1B/1D receptor agonist (K<sub>i</sub> values are 17, 27 and 100 nM at 5-HT<sub>1D</sub>, 5-HT<sub>1B</sub> and 5-HT<sub>1A</sub> receptors respectively). Shows antimigraine activity. Hello Bio HB1769
      7-TM Receptors Tocris Bioscience 3586
      GPCR/G protein MedChem Express HY-B0121
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0121
      Neuroscience TargetMol T0203
      Receptors & Transporters/G protein coupled receptors/5-HT/5-HT<sub>1</sub>/5-HT<sub>1A</sub> Hello Bio HB1769
      Receptors & Transporters/G protein coupled receptors/5-HT/5-HT<sub>1</sub>/5-HT<sub>1B</sub> Hello Bio HB1769
      Receptors & Transporters/G protein coupled receptors/5-HT/5-HT<sub>1</sub>/5-HT<sub>1D</sub> Hello Bio HB1769
      Sumatriptan succinate is a serotonin1 (5-HT1) receptor agonist, which is effective in the acute treatment of migraine headache. MedChem Express
      Sumatriptan succinate is a serotonin1 (5-HT1) receptor agonist, which is effective in the acute treatment of migraine headache.; Target: 5-HT 1d receptor agonist; Sumatriptan succinate is a serotonin1 (5-HT1) receptor agonist, which is effective in the acute treatment of migraine headache. MedChem Express HY-B0121
      Sumatriptan succinate is a serotonin1 (5-HT1) receptor agonist, which is effective in the acute treatment of migraine headache.;Target: 5-HT 1d receptor agonistSumatriptan succinate is a serotonin1 (5-HT1) receptor agonist, which is effective in the acute treatment of migraine headache. Its antimigraine activity is believed to derive from selective vasoconstriction of cranial blood vessels which are dilated and distended during migraine headache and/or from inhibition of neurogenically mediated inflammation in the dura mater [1].For sumatriptan succinate 50 mg versus placebo the NNTs were 6.1, 7.5, and 4.0 for pain-free at two hours and headache relief at one and two hours, respectively. NNTs for sustained pain-free and sustained headache relief during the 24 hours postdose were 9.5 and 6.0, respectively [2]. Difference in time-weighted (0-2.5 h) mean arterial pressure MAP (90% confidence interval) was 1.2 mmHg (-0.2, 2.7) between telcagepant and placebo, 4.0 mmHg (2.5, 5.5) betw MedChem Express HY-B0121
      Type/Biochemicals & small molecules/Agonists & activators Hello Bio HB1769

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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