ChemSpider 2D Image | Amlodipine besylate | C26H31ClN2O8S

Amlodipine besylate

  • Molecular FormulaC26H31ClN2O8S
  • Average mass567.051 Da
  • Monoisotopic mass566.148987 Da
  • ChemSpider ID54537

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

103129-81-3 [RN]
111470-99-6 [RN]
2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate
2-Ethoxybenzoic acid [ACD/IUPAC Name]
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, benzenesulfonate (1:1) [ACD/Index Name]
3-Ethyl 5-Methyl (±)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate Monobenzenesulfonate
3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate benzenesulfonate
3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate benzenesulfonate (1:1) [ACD/IUPAC Name]
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate
3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate (1:1)
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

5K09K116QG [DBID]
885H5YC40L [DBID]
A5605_SIGMA [DBID]
D00615 [DBID]
HSDB 7079 [DBID]
KBio2_001053 [DBID]
KBio2_003621 [DBID]
KBio2_006189 [DBID]
KBioSS_001053 [DBID]
LS-131175 [DBID]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      22-36/37/38 LKT Labs [A5044]
      GHS07 Biosynth Q-200628
      H302 H315 H319 H335 LKT Labs [A5044]
      H302; H315; H319; H335 Biosynth Q-200628
      IRRITANT Matrix Scientific 047879
      None LKT Labs [A5044]
      P261; P262 Biosynth Q-101934
      P261; P280; P302+P352; P304+P340; P305+P351+P338; P312 Biosynth Q-200628
      Warning Biosynth Q-200628
      Xn LKT Labs [A5044]
    • Target Organs:

      Calcium Channel inhibitor TargetMol T1545
      Carbonic anhydrase inhibitor;Calcium Channel inhibitor;PDE inhibitor TargetMol T0231
    • Chemical Class:

      The benzenesulfonate salt of amlodipine. ChEBI CHEBI:2669, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:2669
    • Drug Status:

      USAN, INN, BAN, JAN Microsource [01505202]
    • Compound Source:

      synthetic Microsource [01505202]
    • Bio Activity:

      Amlodipine besylate is a long-acting calcium channel blocker. MedChem Express
      Amlodipine besylate is a long-acting calcium channel blocker.; Target: Calcium Channel; Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. MedChem Express HY-B0317B
      Amlodipine besylate is a long-acting calcium channel blocker.;Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, a MedChem Express HY-B0317B
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio [HB1214]
      CA 1;Calcium Channel;SMPD TargetMol T0231
      Ca2+ channel blocker (L-type) Tocris Bioscience 2571
      Calcium Channel MedChem Express HY-B0317B
      Calcium Channel TargetMol T1545
      Calcium Channels Tocris Bioscience 2571
      Ion Channels Tocris Bioscience 2571
      Ion channels/Voltage-gated ion channel/Calcium Channels Hello Bio [HB1214]
      L-type calcium channel blocker Hello Bio [HB1214]
      L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascu lar disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 ?M). Tocris Bioscience 2571
      L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 ?M). Tocris Bioscience 2571
      L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 muM). Tocris Bioscience 2571
      L-type calcium channel blocker. Decreases eNOS expression in the aorta. Shows antiproliferative, antihypertensive, antioxidant, anti-inflammatory, vasoprotective and neuroprotective actions. Hello Bio [HB1214]
      Membrane Tranporter/Ion Channel MedChem Express HY-B0317B
      Membrane Tranporter/Ion Channel; MedChem Express HY-B0317B
      Membrane Transporter/Ion Channel TargetMol T1545
      Membrane Transporter/Ion Channel; Metabolism TargetMol T0231
      Voltage-gated Calcium Channels Tocris Bioscience 2571

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site






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