Lysergic acid diethylamide , LSD, LSD-25, or acid, is a semisynthetic psychedelic drug of the ergoline family. Probably the most widely known psychedelic, it has been used mainly as a recreational drug, an entheogen, and a tool to supplement various practices for transcendence, including in meditation, psychonautics, art projects, and illicit (though at one time legal) psychedelic therapy, whether self-administered or not. It is synthesized from lysergic acid derived from ergot, a grain fungus that typically grows on rye and was first synthesized by Swiss chemist Albert Hofmann. The short form LSD comes from its early codename ''LSD-25'', which is an abbreviation for the German "Lysergsäure-diethylamid" followed by a sequential number.
LSD is sensitive to oxygen, ultraviolet light, and chlorine, especially in solution, though its potency may last for years if it is stored away from light and moisture at low temperature. In pure form it is colorless, odorless, and mildly bitter. LSD is typically delivered orally, usually on a substrate such as absorbent blotter paper, a sugar cube, or gelatin. In its liquid form, it can be administered by intramuscular or intravenous injection. The threshold dosage level needed to cause a psychoactive effect on humans is of the order of 20 to 30 µg (micrograms).
Introduced by Sandoz Laboratories as a drug with various psychiatric uses, LSD quickly became a therapeutic agent that appeared to show great promise. However, the extra-medicinal use of the drug in Western society during the mid-twentieth century led to a political firestorm that resulted in the banning of the substance. A number of organizations—including the Beckley Foundation, MAPS, Heffter Research Institute and the Albert Hofmann Foundation—exist to fund, encourage and coordinate research into its medicinal uses.
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experimental physchem properties
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The melting point of a crystalline solid is the temperature range at which it changes state from solid to liquid. See also: Melting Point
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miscellaneous
Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Redirected by Users, Redirect Approved by Experts
| (+)-LSD |
| (8beta)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide |
| 200-033-2[EINECS] |
| 50-37-3[RN] |
| 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide |
| 9,10-Didehydro-N,N-diethyl-6-methyl-ergoline-8-beta-carboxamide |
| Blotter Acid |
| Blue Acid |
| Blue Cheer |
| Blue Mist |
| Blue Star |
| D-Lysergic acid diethylamide |
| Ergoline-8beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- |
| Ergoline-8-beta-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- |
| Ergoline-8-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl-, (8beta)- |
| LSD |
| LYSERGIC ACID DIETHYLAMIDE |
| Lysergide |
| Lysergsaure Diethylamid |
| N,N-Diethyl-D-lysergamide |
| (+)-Lysergic acid diethylamide |
| 4-25-00-00939 (Beilstein Handbook Reference) |
| Delysid[Wiki] |
| Diethylamid kyseliny lysergove[Czech] |
| Ergoline-8b-carboxamide, 9,10-didehydro-N,N-diethyl-6-methyl- (8CI) |
| Lisergide [DCIT] |
| Lisergido[Spanish] |
| Lysergamid |
| Lysergamide, N,N-diethyl- |
| Lysergaure diethylamid |
| Lysergic acid diethylamide-25 |
| Lysergide [BAN:DCF:INN] |
| Lysergide LSD |
| LYSERGIDE, L- |
| Lysergidum[Latin] |
| Lysergsaeurediaethylamid |
| N,N-Diethyllysergamide |
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Redirected by Users, Redirect Approved by Experts
| LSD-25 |
| BRN 0094179 |
| C07542 |
| DEA No. 7315 |
| HSDB 3920 |
| LSD 25 |
Show Edit Synonym Window
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LogP: |
ACD/LogP:
2.74
XLogP:
2.10
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# of Rule of 5 Violations: |
0
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ACD/LogD (pH 5.5): |
0.5
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ACD/LogD (pH 7.4): |
2.19
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ACD/BCF (pH 5.5): |
1
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ACD/BCF (pH 7.4): |
20.3
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ACD/KOC (pH 5.5): |
4.27
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ACD/KOC (pH 7.4): |
210.6
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#H bond acceptors: |
4
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#H bond donors: |
1
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#Freely Rotating Bonds: |
3
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Polar Surface Area: |
28.48
Å2
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Index of Refraction: |
1.651
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Molar Refractivity: |
97.22
cm3
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Molar Volume: |
266
cm3
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Polarizability: |
38.54
10-24cm3
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Surface Tension: |
55.9
dyne/cm
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Density: |
1.21
g/cm3
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Flash Point: |
281.2
°C
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Enthalpy of Vaporization: |
81.91
kJ/mol
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Boiling Point: |
541.3
°C at 760 mmHg
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Vapour Pressure: |
8.82E-12
mmHg at 25°C
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Descriptors:
0, 0, 0, 1, 1, 0, 0, 3, 0, 0, 0, 0, 13, 3, 6, 1, 9, 2, 1, 0, 2, 0, 0, 0
| Category | Target | PDB Code | LASSO Score |
| Nuclear Hormone Receptors | PPARg, peroxisome proliferator activated receptor | 1fm9 | 0.03 |
| Other Enzymes | InhA, enoyl ACP reductase | 1p44 | 0.02 |
| Kinases | PDGFrb, platelet derived growth factor receptor kinase | N/A | 0.02 |
| Kinases | SRC, tyrosine kinase SRC | 2src | 0.01 |
| Other Enzymes | HMGR, hydroxymethylglutaryl-CoA reductase | 1hw8 | 0.01 |
| Serine Proteases | Thrombin | 1ba8 | 0.01 |
| Other Enzymes | HIVPR, HIV protease | 1hpx | 0.01 |
| Metalloenzymes | PDE5, phosphodiesterase 5 | 1xp0 | 0.01 |
| Nuclear Hormone Receptors | MR, mineralocorticoid receptor | 2aa2 | 0.01 |
| Metalloenzymes | ACE, angiotensin-converting enzyme | 1o86 | 0.01 |
| Other Enzymes | PARP, poly(ADP-ribose) polymerase | 1efy | 0.01 |
| Other Enzymes | PNP, purine nucleoside phosphorylase | 1b8o | 0.00 |
| Other Enzymes | AmpC, AmpC beta-lactamase | 1xgj | 0.00 |
| Nuclear Hormone Receptors | ER, estrogen receptor; agonist | 1l2i | 0.00 |
| Nuclear Hormone Receptors | PR, progesterone receptor | 1sr7 | 0.00 |
| Folate Enzymes | DHFR, dihydrofolate reductase | 3dfr | 0.00 |
| Kinases | VEGFr2, vascular endothelial growth factor receptor | 1vr2 | 0.00 |
| Other Enzymes | GPB, glycogen phosphorylase | 1a8i | 0.00 |
| Other Enzymes | SAHH, S-adenosyl-homocysteine hydrolase | 1a7a | 0.00 |
| Kinases | FGFr1, fibroblast growth factor receptor kinase | 1agw | 0.00 |
| Other Enzymes | COX-2, cyclooxygenase-2 | 1cx2 | 0.00 |
| Other Enzymes | ALR2, aldose reductase | 1ah3 | 0.00 |
| Kinases | CDK2, cyclindependent kinase 2 | 1ckp | 0.00 |
| Nuclear Hormone Receptors | RXRa, retinoic X receptor R | 1mvc | 0.00 |
| Other Enzymes | NA, neuraminidase | 1a4g | 0.00 |
| Kinases | TK, thymidine kinase | 1kim | 0.00 |
| Metalloenzymes | ADA, adenosine deaminase | 1stw | 0.00 |
| Kinases | P38 MAP, P38 mitogen activated protein | 1kv2 | 0.00 |
| Nuclear Hormone Receptors | AR, androgen receptor | 1xq2 | 0.00 |
| Serine Proteases | FXa, factor Xa | 1f0r | 0.00 |
| Folate Enzymes | GART, glycinamide ribonucleotide transformylase | 1c2t | 0.00 |
| Metalloenzymes | COMT, catechol O-methyltransferase | 1h1d | 0.00 |
| Kinases | HSP90, human heat shock protein 90 | 1uy6 | 0.00 |
| Other Enzymes | HIVRT, HIV reverse transcriptase | 1rt1 | 0.00 |
| Other Enzymes | AChE, acetylcholinesterase | 1eve | 0.00 |
| Kinases | EGFr, epidermal growth factor receptor | 1m17 | 0.00 |
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