ChemSpider 2D Image | Sildenafil citrate | C28H38N6O11S

Sildenafil citrate

  • Molecular FormulaC28H38N6O11S
  • Average mass666.700 Da
  • Monoisotopic mass666.231934 Da
  • ChemSpider ID56586

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Viagra [Trade name]
1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt
171599-83-0 [RN]
1H-pyrazolo[4,3-d]pyrimidin-7-ol, 5-[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1-methyl-3-propyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
2-Ethoxybenzoic acid [ACD/IUPAC Name]
2-Hydroxy-1,2,3-propantricarbonsäure --5-{2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-on (1:1) [German] [ACD/IUPAC Name]
2-Hydroxypropan-1,2,3-tricarbonsäure--5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-on(1:1)
5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt
5-{2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]phenyl}-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxy-1,2,3-propanetricarboxylate (1:1) [ACD/IUPAC Name]
5-{2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

9892846 [DBID]
D02229 [DBID]
LS-111685 [DBID]
UK 92480 [DBID]
UK 92480-10 [DBID]
UK-92480 [DBID]
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      DMSO 23 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL MedChem Express HY-15025A
      DMSO:50 mg/ml;ethanol:50 mg/ml;DMF:20 mg/ml; MedChem Express HY-15025A
      Soluble in DMSO Axon Medchem 2046
      Soluble to 100 mM in DMSO Tocris Bioscience 3784
  • Miscellaneous

    • Appearance:

      White to off-white powder Chemodex S0078

    • Safety:

      5 Axon Medchem 2046
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 2046
      no pictogram Axon Medchem 2046
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 2046
      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 3784
      Warning Axon Medchem 2046
      Xi Abblis Chemicals AB1009362

    • Target Organs:

      PDE inhibitor TargetMol T0467

    • Chemical Class:

      The citrate salt of sildenafil. ChEBI CHEBI:58987

    • Bio Activity:

      Enzymes Tocris Bioscience 3784
      Metabolic Enzyme/Protease; MedChem Express HY-15025A
      Metabolism TargetMol T0467
      Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Tocris Bioscience 3784
      Orally active, potent PDE5 inhibitor Tocris Bioscience 3784
      Others MedChem Express HY-15025A
      PDE MedChem Express HY-15025A
      PDE5, PDE6 TargetMol T0467
      Phosphodiesterases Tocris Bioscience 3784
      Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. MedChem Express
      Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.; IC50 Value: 5.22 nM [1]; Target: PDE 5; in vitro: Pretreatment with 1 umol/L sildenafil potentiated the phosphorylation of ERK1/ERK2, an increase in the percentage of cells in S phase and cell proliferation, compared with serotonin stimulation alone (P < 0.05) [2]. MedChem Express HY-15025A
      Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.;IC50 Value: 5.22 nM [1];Target: PDE 5;In vitro: Pretreatment with 1 umol/L sildenafil potentiated the phosphorylation of ERK1/ERK2, an increase in the percentage of cells in S phase and cell proliferation, compared with serotonin stimulation alone (P < 0.05) [2]. pretreatment of cells with sildenafilsuppressed serotonin-triggered activation of calcineurin/NFATc2 signaling pathway and resultant cyclin A expression, CDK2 activation and cell proliferation, while the presence of DT-3 [a specific protein kinase G (PKG) peptide inhibitor] reversed the effects of sildenafil on PASMCs [4].;In vivo: Sildenafil at a dose ranging from 10 to 40mg/kg statistically increased psychomotor seizure threshold in mice. Moreover, sildenafil enhanced the anticonvulsant action of all the studied AEDs in this test [3]. Administration of oral sildenafil MedChem Express HY-15025A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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