Fluoxetine Hydrochloride

Molecular FormulaC₁₇H₁₉ClF₃NO
Average mass345.787 Da
Monoisotopic mass345.110718 Da
ChemSpider ID56589

More details:

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Fluoxetine Hydrochloride [INN]

(±)-N-Methyl-3-phenyl-3-[(a,a,a-trifluoro-p-tolyl)oxy]propylamine Hydrochloride

(±)-N-Methyl-g-[4-(trifluoromethyl)phenoxy]benzenepropanamine Hydrochloride

(±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride

260-101-2 [EINECS]

56296-78-7 [RN]

Benzenepropanamine, N-methyl-γ-[4-(trifluoromethyl)phenoxy]-, hydrochloride (1:1) [ACD/Index Name]

Fluoxetine HCl

Fluoxetine HCL

FLUOXETINE HYDROCHLORIDE, (R)-

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

34012_RIEDEL [DBID]

7C4D25ST1T [DBID]

Alzac 20 [DBID]

CCRIS 6150 [DBID]

CCRIS 7093 [DBID]

D00823 [DBID]

EU-0100558 [DBID]

F132_SIGMA [DBID]

Lilly 110140 [DBID]

LY 110140 [DBID]

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Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Experimental Physico-chemical Properties

Experimental Solubility:

Predicted Physico-chemical Properties
- Predicted Melting Point:
  
  159 °C TCI
  
  159 °C TCI F0750

Miscellaneous

Appearance:

Stability:

Stable. Incompatible with strong oxidizing agents. Oxford University Chemical Safety Data (No longer updated) More details
Toxicity:

ORL-RAT LD50 452 mg kg-1, ORL-MUS LD50 248 mg kg-1, IPR-MUS LD50 100 mg kg-1 Oxford University Chemical Safety Data (No longer updated) More details

Safety:

Target Organs:

5-HT Receptor antagonist TargetMol T0450L
Compound Source:

synthetic Microsource [01504173]

Bio Activity:

5-HT receptor;Sodium-dependent serotonin transporter TargetMol T0450L

5-HT reuptake inhibitor Tocris Bioscience 927

5-HT re-uptake inhibitor Tocris Bioscience 0927, 927

5-HT Transporters Tocris Bioscience 927

Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. MedChem Express

Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.; Target: 5-HT Receptor; Fluoxetine HCl, a specific inhibitor of serotonin re-uptake in brain, are less sensitive to electroshock. MedChem Express HY-B0102A

Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.;Target: 5-HT ReceptorFluoxetine HCl, a specific inhibitor of serotonin re-uptake in brain, are less sensitive to electroshock. Fluoxetine HCl antagonizes the hyperalgesia following injections of p-chlorophenylalanine and potentiates morphine analgesia. Naloxone blocks the analgesia following morphine, but has no effect on Fluoxetine HCl-induced analgesia. Brain serotonin neurons may, at least in part, mediate analgesia [1]. Administration of fluoxetine (10 mg/kg, i.p.) alone also decreased the number of spontaneously active serotonergic neurons. However, when administered following fluoxetine, pindolol significantly attenuated, but did not block completely, the inhibitory effects of fluoxetine on the number of spontaneously active serotonergic neurons. These results indicate that pindolol can attenuate the effects of fluoxetine on the firing of serotonergic neurons. These results may hel MedChem Express HY-B0102A

Neuronal Signaling MedChem Express HY-B0102A

Neuronal Signaling; MedChem Express HY-B0102A

Neuroscience TargetMol T0450L

Neurotransmitter Transporters Tocris Bioscience 927

Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, ?1, ?2-adrenergic, and muscarin ic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Also available as part of the Serotonin Uptake Inhibitor Tocriset™. Tocris Bioscience 0927

Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, ?1, ?2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Tocris Bioscience 927

Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, alpha1, alpha2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Tocris Bioscience 927

SSRIs MedChem Express HY-B0102A

Transporters Tocris Bioscience 927

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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Click to predict properties on the Chemicalize site

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Fluoxetine Hydrochloride

More details:

Experimental Melting Point:

Experimental Solubility:

Predicted Melting Point:

Appearance:

Stability:

Toxicity:

Safety:

Target Organs:

Compound Source:

Bio Activity:

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