ChemSpider 2D Image | Fluoxetine Hydrochloride | C17H19ClF3NO

Fluoxetine Hydrochloride

  • Molecular FormulaC17H19ClF3NO
  • Average mass345.787 Da
  • Monoisotopic mass345.110718 Da
  • ChemSpider ID56589

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Fluoxetine Hydrochloride [INN]
(±)-N-Methyl-3-phenyl-3-[(a,a,a-trifluoro-p-tolyl)oxy]propylamine Hydrochloride
(±)-N-Methyl-g-[4-(trifluoromethyl)phenoxy]benzenepropanamine Hydrochloride
(±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride
260-101-2 [EINECS]
56296-78-7 [RN]
Benzenepropanamine, N-methyl-γ-[4-(trifluoromethyl)phenoxy]-, hydrochloride (1:1) [ACD/Index Name]
Fluoxetine HCl
Fluoxetine HCL
FLUOXETINE HYDROCHLORIDE, (R)-
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

34012_RIEDEL [DBID]
7C4D25ST1T [DBID]
Alzac 20 [DBID]
CCRIS 6150 [DBID]
CCRIS 7093 [DBID]
D00823 [DBID]
EU-0100558 [DBID]
F132_SIGMA [DBID]
Lilly 110140 [DBID]
LY 110140 [DBID]
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  • Experimental Physico-chemical Properties

    • Experimental Melting Point:

      159 °C TCI F0750
      158.4 °C LKT Labs [F4780]
      158-159 °C Matrix Scientific
      158-159 °C Matrix Scientific 047891
      157 °C (Decomposes) LabNetwork LN00149815

    • Experimental Solubility:

      50 mg/ml in H2O MedChem Express HY-B0102A
      DMSO 68 mg/ml; Water 4 mg/ml; Ethanol 68 mg/mL MedChem Express HY-B0102A
      Soluble in DMSO Axon Medchem 1302
      Soluble in methanol, ethanol, acetone, acetonitrile and chloroform. Water to 10 mM, DMSO to 100 mM. DMF to 16 mg/mL.Ethanol to 69mg/mL LKT Labs [F4780]
      Soluble to 100 mM in DMSO and to 10 mM in water Tocris Bioscience 0927, 927
  • Predicted Physico-chemical Properties
  • Miscellaneous

    • Appearance:

      solid Oxford University Chemical Safety Data (No longer updated) More details
      WHITE POWDER NIH Clinical Collection [SMR000058452]

    • Stability:

      Stable. Incompatible with strong oxidizing agents. Oxford University Chemical Safety Data (No longer updated) More details

    • Toxicity:

      ORL-RAT LD50 452 mg kg-1, ORL-MUS LD50 248 mg kg-1, IPR-MUS LD50 100 mg kg-1 Oxford University Chemical Safety Data (No longer updated) More details

    • Safety:

      22 LKT Labs [F4780]
      302 LKT Labs [F4780]
      5 Axon Medchem 1302
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1302
      IRRITANT Matrix Scientific 047891
      no pictogram Axon Medchem 1302
      Not Dangerous Goods LKT Labs [F4780]
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1302
      Safety glasses if handling the powder, adequate ventilation. Oxford University Chemical Safety Data (No longer updated) More details
      Sold with the permission of Eli Lilly and Company Tocris Bioscience 927
      Warning Axon Medchem 1302
      Xn LKT Labs [F4780]

    • Target Organs:

      5-HT Receptor antagonist TargetMol T0450L

    • Drug Status:

      approved BIONET-Key Organics KS-1061

    • Compound Source:

      synthetic Microsource [01504173]

    • Bio Activity:

      5-HT receptor;Sodium-dependent serotonin transporter TargetMol T0450L
      5-HT reuptake inhibitor Tocris Bioscience 927
      5-HT re-uptake inhibitor Tocris Bioscience 0927, 927
      5-HT Transporters Tocris Bioscience 927
      Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. MedChem Express
      Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.; Target: 5-HT Receptor; Fluoxetine HCl, a specific inhibitor of serotonin re-uptake in brain, are less sensitive to electroshock. MedChem Express HY-B0102A
      Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.;Target: 5-HT ReceptorFluoxetine HCl, a specific inhibitor of serotonin re-uptake in brain, are less sensitive to electroshock. Fluoxetine HCl antagonizes the hyperalgesia following injections of p-chlorophenylalanine and potentiates morphine analgesia. Naloxone blocks the analgesia following morphine, but has no effect on Fluoxetine HCl-induced analgesia. Brain serotonin neurons may, at least in part, mediate analgesia [1]. Administration of fluoxetine (10 mg/kg, i.p.) alone also decreased the number of spontaneously active serotonergic neurons. However, when administered following fluoxetine, pindolol significantly attenuated, but did not block completely, the inhibitory effects of fluoxetine on the number of spontaneously active serotonergic neurons. These results indicate that pindolol can attenuate the effects of fluoxetine on the firing of serotonergic neurons. These results may hel MedChem Express HY-B0102A
      Neuronal Signaling MedChem Express HY-B0102A
      Neuronal Signaling; MedChem Express HY-B0102A
      Neuroscience TargetMol T0450L
      Neurotransmitter Transporters Tocris Bioscience 927
      Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, ?1, ?2-adrenergic, and muscarin ic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Also available as part of the Serotonin Uptake Inhibitor Tocriset™. Tocris Bioscience 0927
      Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, ?1, ?2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Tocris Bioscience 927
      Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, alpha1, alpha2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Tocris Bioscience 927
      Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, alpha1, alpha2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Deuterated analog also available. Tocris Bioscience 927
      SSRIs MedChem Express HY-B0102A
      Transporters Tocris Bioscience 927

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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