ChemSpider 2D Image | GDC-0084 | C18H22N8O2


  • Molecular FormulaC18H22N8O2
  • Average mass382.420 Da
  • Monoisotopic mass382.186584 Da
  • ChemSpider ID57251291

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1382979-44-3 [RN]
2-Pyrimidinamine, 5-[8,9-dihydro-6,6-dimethyl-4-(4-morpholinyl)-6H-[1,4]oxazino[4,3-e]purin-2-yl]- [ACD/Index Name]
5-[6,6-Dimethyl-4-(4-morpholinyl)-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl]-2-pyrimidinamin [German] [ACD/IUPAC Name]
5-[6,6-Dimethyl-4-(4-morpholinyl)-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl]-2-pyrimidinamine [ACD/IUPAC Name]
5-[6,6-Diméthyl-4-(4-morpholinyl)-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl]-2-pyrimidinamine [French] [ACD/IUPAC Name]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      GDC-0084 is a potent, selective inhibitor of Class I PI3K and mTOR with good penetration across the blood-brain barrier.[1] [2];Target : PI3K, mToR MedChem Express HY-19962
      mTOR PI3K MedChem Express HY-19962
      PI3K/Akt/mTOR; MedChem Express HY-19962

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.6±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.789
Molar Refractivity: 100.8±0.5 cm3
#H bond acceptors: 10
#H bond donors: 2
#Freely Rotating Bonds: 2
#Rule of 5 Violations: 1
ACD/LogP: -0.76
ACD/LogD (pH 5.5): 0.75
ACD/BCF (pH 5.5): 2.19
ACD/KOC (pH 5.5): 60.97
ACD/LogD (pH 7.4): 0.75
ACD/BCF (pH 7.4): 2.19
ACD/KOC (pH 7.4): 61.07
Polar Surface Area: 117 Å2
Polarizability: 40.0±0.5 10-24cm3
Surface Tension: 69.5±7.0 dyne/cm
Molar Volume: 238.2±7.0 cm3

Click to predict properties on the Chemicalize site