ChemSpider 2D Image | Plerixafor 8HCl | C28H62Cl8N8

Plerixafor 8HCl

  • Molecular FormulaC28H62Cl8N8
  • Average mass794.469 Da
  • Monoisotopic mass790.260559 Da
  • ChemSpider ID58530

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,1'-(1,4-Phenylendimethylen)bis-1,4,8,11-tetraazacyclotetradecanoctahydrochlorid [German] [ACD/IUPAC Name]
1,1'-(1,4-Phénylènediméthylène)bis-1,4,8,11-tétraazacyclotétradécane, octachlorhydrate [French] [ACD/IUPAC Name]
1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride [ACD/IUPAC Name]
1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-, hydrochloride (1:8) [ACD/Index Name]
1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrochloride
Plerixafor 8HCl
Plerixafor octahydrochloride
UNII:OD49913540
[155148-31-5] [RN]
1,1'-(1,4-Phenylenebis(methylene))bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

AMD 3100 [DBID]
AMD3100 [DBID]
JM 3100 [DBID]
JM-3100 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 3299
      Chemokine CXC Receptors Tocris Bioscience 3299
      Chemokine Receptors Tocris Bioscience 3299
      CXCR MedChem Express HY-50912
      GPCR/G protein MedChem Express HY-50912
      GPCR/G protein; Immunology/Inflammation; MedChem Express HY-50912
      Highly selective CXCR4 antagonist Tocris Bioscience 3299
      Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 ?M for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. Tocris Bioscience 3299
      Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 ?M for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. Tocris Bioscience 3299
      Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 muM for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. Attenuates cocaine place preference and locomotor stimulation in rats. Attenuates microglial activation neurological function after ischemic stroke in mice. Tocris Bioscience 3299
      Plerixafor octahydrochloride(AMD3100 8HCL) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. MedChem Express
      Plerixafor octahydrochloride(AMD3100 8HCL) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.; IC50 value: 44 nM (CXCR4); 5.7 nM (CXCL12-mediated chemotaxis); Target: CXCR4; in vitro: Plerixafor inhibits CXCL12-mediated chemotaxis with a potency lightly better than its affinity for CXCR4. MedChem Express HY-50912
      Plerixafor octahydrochloride(AMD3100 8HCL) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.;IC50 value: 44 nM (CXCR4); 5.7 nM (CXCL12-mediated chemotaxis);Target: CXCR4;In vitro: Plerixafor inhibits CXCL12-mediated chemotaxis with a potency lightly better than its affinity for CXCR4. Plerixafor also antagonizes SDF-1/CXCL12 ligand binding with an IC50 of 651 nM. Plerixafor inhibits SDF-1 mediated GTP-binding, SDF-1 mediated calcium flux and SDF-1 stimulated chemotaxis with IC50 of 27 nM, 572 nM and 51 nM, respectively. Plerixafor does not inhibit calcium flux against cells expressing CXCR3, CCR1, CCR2b, CCR4, CCR5 or CCR7 when stimulated with their cognate ligands, nor does Plerixafor inhibit receptor binding of LTB4. Plerixafor does not, on its own, induce a calcium flux in the CCRF?CEM cells, which express multiple GPCRs including CXCR4, CCR4 and CCR7.;In vivo: A single topical application of Plerixafor prom MedChem Express HY-50912

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


Advertisement