ChemSpider 2D Image | Betahistine Dihydrochloride | C8H14Cl2N2

Betahistine Dihydrochloride

  • Molecular FormulaC8H14Cl2N2
  • Average mass209.116 Da
  • Monoisotopic mass208.053406 Da
  • ChemSpider ID61900

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Betahistine Dihydrochloride
226-966-5 [EINECS]
2-Pyridineethanamine, N-methyl-, hydrochloride (1:2) [ACD/Index Name]
5579-84-0 [RN]
Betahistine (hydrochloride)
Betahistine Hydrochloride [USP]
Betahistine hydrochloride (USP)
Methyl[2-(2-pyridyl)ethyl]amine dihydrochloride
methyl[2-(pyridin-2-yl)ethyl]amine dihydrochloride
N-Methyl-2-(2-pyridinyl)ethanamindihydrochlorid [German] [ACD/IUPAC Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

49K58SMZ7U [DBID]
MFCD00012813 [DBID]
D03102 [DBID]
UNII:49K58SMZ7U [DBID]
UNII-49K58SMZ7U [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Histamine Receptor antagonist TargetMol T0246

    • Bio Activity:

      Betahistine Dihydrochloride is a histamine H3 receptors inhibitor used as an antivertigo drug. MedChem Express
      Betahistine Dihydrochloride is a histamine H3 receptors inhibitor used as an antivertigo drug.; Target: Histamine Receptor; Betahistine, a structural analogue of histamine with weak histamine H(1) receptor agonist and more potent H(3) receptor antagonist properties. MedChem Express HY-B0524A
      Betahistine Dihydrochloride is a histamine H3 receptors inhibitor used as an antivertigo drug.;Target: Histamine ReceptorBetahistine, a structural analogue of histamine with weak histamine H(1) receptor agonist and more potent H(3) receptor antagonist properties. Betahistine acts centrally by enhancing histamine synthesis within tuberomammillary nuclei of the posterior hypothalamus and histamine release within vestibular nuclei through antagonism of H(3) autoreceptors [1].;Therapeutic effects of betahistine in vestibular disorders result from its antagonist properties at histamine H(3) receptors (H(3)Rs). On inhibition of cAMP formation and [(3)H]arachidonic acid release, betahistine behaved as a nanomolar inverse agonist and a micromolar agonist. After acute oral administration, Betahistine increased t-MeHA levels with an ED(50) of 2 mg/kg, a rightward shift probably caused by almost complete first-pass metabolism. Therapeutic effects of betahistine result from an enhancement of MedChem Express HY-B0524A
      GPCR/G protein MedChem Express HY-B0524A
      GPCR/G protein; MedChem Express HY-B0524A
      Histamine H1, H3 receptor TargetMol T0246
      Histamine Receptor MedChem Express HY-B0524A
      Neuroscience TargetMol T0246

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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