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Dihydroergotamine mesylate

Molecular FormulaC₃₄H₄₁N₅O₈S
Average mass679.783 Da
Monoisotopic mass679.267578 Da
ChemSpider ID64311

- 7 of 7 defined stereocentres

More details:

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(5'α,10α)-5'-Benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman methanesulfonate (1:1) [ACD/IUPAC Name]

(5'α,10α)-5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman methanesulfonate (salt)

(6aR,9R,10aR)-N-[(2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-[1,3]oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-ca

(6aR,9R,10aR)-N-[(2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-[1,3]oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide methanesulfonate (salt)

228-235-6 [EINECS]

6190-39-2 [RN]

81AXN7R2QT

Acide méthanesulfonique - (5'α,10α)-5'-benzyl-12'-hydroxy-2'-méthyl-3',6',18-trioxo-9,10-dihydroergotaman (1:1) [French] [ACD/IUPAC Name]

acide méthanesulfonique - (6aR,9R,10aR)-N-[(2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-méthyl-3,6-dioxooctahydro-8H-[1,3]oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-méthyl-4,6,6a,7,8,9,10,10a-octahydroin

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Dihydroergotamine (mesylate)

Dihydroergotamine mesylate [USP]

dolo[4,3-fg]quinoléine-9-carboxamide (1:1)

Ergotaman, 9,10-dihydro-12'-hydroxy-2'-methyl-3',6',18-trioxo-5'-(phenylmethyl)-, (5'α,10α)-, methanesulfonate (1:1) (salt) [ACD/Index Name]

Methansulfonsäure --(5'α,10α)-5'-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman (1:1) [German] [ACD/IUPAC Name]

Methansulfonsäure--(6aR,9R,10aR)-N-[(2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-[1,3]oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,

rboxamide methanesulfonate (salt)

(10αH)-5'α-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman mesylate

(10αH)-5'α-benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman methanesulfonate

(2R,4R,7R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.0^2,6]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraene-4-carboxamide; methanesulfonic acid

(6aR,9R,10aR)-N-[(2R,5S,10aS,10bS)-5-Benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide methanesulfonate

[6190-39-2] [RN]

9,10-Dihydro-12¢-hydroxy-2¢-methyl-5¢-(phenylmethyl)ergotaman-3¢,6¢,18-trione mesylate

9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione mesylate

9,10-Dihydroergotamine mesylate

9,10-dihydroergotamine methanesulfonate

D.H.E. 45

DETMS

dihydergot

dihydroergotamine [INN] [Wiki]

Dihydroergotamine mesilate [JP15]

Dihydroergotamine mesilate (JP15)

Dihydroergotamine mesylate (USP)

Dihydroergotamine mesylate [USAN] [USAN]

Dihydroergotamine methanesulfonate

Dihydroergotamine methanesulfonate salt

Dihydroergotamine monomethanesulfonate

DIHYDROERGOTAMINE; METHANESULFONIC ACID

Dihytamine

EINECS 228-235-6

Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-methyl-5'-(phenylmethyl)-, (5'?,10?)-, monomethanesulfonate (salt)

Ergotamine, 9,10-dihydro-, monomethanesulfonate (salt)

ergotamine, dihydro-, mesylate

Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'α)-, monomethanesulfonate (salt)

KE7920000

Methanesulfonic acid [ACD/Index Name] [ACD/IUPAC Name] [Wiki]

MFCD05618219

Migranal [Trade name] [Wiki]

Migranal (TN)

Pharmakon1600-01500248

SPECTRUM1500248

ST056346

UNII:81AXN7R2QT

UNII-81AXN7R2QT

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

DHE 45 [DBID]

3895588 [DBID]

D02211 [DBID]

D2763_SIGMA [DBID]

DHE-45 [DBID]

EU-0100357 [DBID]

MT 300 [DBID]

Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Experimental Physico-chemical Properties

Experimental Melting Point:

232 °C Parchem – fine & specialty chemicals 29981
Experimental Refraction Index:

-20 Parchem – fine & specialty chemicals 29981

Experimental Solubility:

Miscellaneous

Target Organs:

5-HT Receptor antagonist TargetMol T0524

Chemical Class:

Bio Activity:

5-HT Receptor MedChem Express HY-B0670A

5-HT Receptor TargetMol T0524

7-TM Receptors Tocris Bioscience 475

Adrenergic Receptors Tocris Bioscience 475

Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB1612

Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines. MedChem Express

Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines.; Target: 5-HT Receptors; Dihydroergotamine is not as effective as sumatriptan or phenothiazines as a single agent for treatment of acute migraine headache; however, when administered with an antiemetic, dihydroergotamine appears to be as effective as opiates, ketorolac, or valproate. MedChem Express HY-B0670A

Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines.;Target: 5-HT ReceptorsDihydroergotamine is not as effective as sumatriptan or phenothiazines as a single agent for treatment of acute migraine headache; however, when administered with an antiemetic, dihydroergotamine appears to be as effective as opiates, ketorolac, or valproate. Given its nonnarcotic properties, parenteral dihydroergotamine combined with an antiemetic should be considered as effective initial therapy in clinical practice [1]. The introduction of the intranasal formulation of DHE provides both pharmacologic and patient-convenience advantages for use in migraine therapy [2, 3]. MedChem Express HY-B0670A

GPCR/G protein MedChem Express HY-B0670A

GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0670A

Neuroscience TargetMol T0524

Non-selective Adrenergic Alpha Receptors Tocris Bioscience 475

Partial α-adrenergic agonist, partial D<sub>2</sub> agonist and 5-HT antagonist Hello Bio HB1612

Partial α-adrenergic agonist. Also partial D<sub>2</sub> receptor agonist and competitive 5-HT antagonist. Hello Bio HB1612

Partial ? agonist. Non-selective Tocris Bioscience 0475, 475

Partial ?-adrenergic agonist. Partial D2 dopaminergic receptor agonist. Competitive 5-HT antagonist. Tocris Bioscience 0475, 475

Partial alpha agonist. Non-selective Tocris Bioscience 475

Partial alpha-adrenergic agonist. Partial D2 dopaminergic receptor agonist. Competitive 5-HT antagonist. Tocris Bioscience 475

Receptors & Transporters/G protein coupled receptors/Adrenoceptors/α/Non-selective Hello Bio HB1612

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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Click to predict properties on the Chemicalize site

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Dihydroergotamine mesylate

More details:

Experimental Melting Point:

Experimental Refraction Index:

Experimental Solubility:

Target Organs:

Chemical Class:

Bio Activity:

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