ChemSpider 2D Image | Ranolazine 2HCl | C24H35Cl2N3O4

Ranolazine 2HCl

  • Molecular FormulaC24H35Cl2N3O4
  • Average mass500.458 Da
  • Monoisotopic mass499.200470 Da
  • ChemSpider ID64403

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2',6'-xylidide dihydrochloride
1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, hydrochloride (1:2) [ACD/Index Name]
95635-56-6 [RN]
MFCD03788770 [MDL number]
N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl}acetamiddihydrochlorid [German] [ACD/IUPAC Name]
N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl}acetamide dihydrochloride [ACD/IUPAC Name]
N-(2,6-Diméthylphényl)-2-{4-[2-hydroxy-3-(2-méthoxyphénoxy)propyl]-1-pipérazinyl}acétamide, dichlorhydrate [French] [ACD/IUPAC Name]
N-(2,6-Dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}acetamide dihydrochloride
N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride
Ranolazine 2HCl
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

F71253DJUN [DBID]
UNII:F71253DJUN [DBID]
EU-0101062 [DBID]
R6152_SIGMA [DBID]
RS 43285 [DBID]
RS-43285 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Sodium Channel;Calcium Channel TargetMol T0207

    • Chemical Class:

      Lipid EU-OpenScreen [R 6152]

    • Bio Activity:

      Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching su bstrate utilization from fatty acids to glucose. Also shown to inhibit late INa and IKr currents. Tocris Bioscience 3118
      Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late INa and IKr currents. Tocris Bioscience 3118
      Antianginal, activates pyruvate dehydrogenase Tocris Bioscience 3118
      Calcium Channel MedChem Express HY-17401
      Dehydrogenases Tocris Bioscience 3118
      Enzymes Tocris Bioscience 3118
      Membrane Tranporter/Ion Channel MedChem Express HY-17401
      Membrane Tranporter/Ion Channel; MedChem Express HY-17401
      Membrane Transporter/Ion Channel TargetMol T0207
      Other Dehydrogenases Tocris Bioscience 3118
      Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), witho ut affecting heart rate or blood pressure (BP). MedChem Express http://www.medchemexpress.com/pamabrom.html
      Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). MedChem Express HY-17401
      Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). ;IC50 value:;Target: sodium-dependent calcium channelRanolazine is currently approved for use in chronic angina. The basis for this use is likely related to inhibition of late sodium channels with resultant beneficial downstream effects. Randomized clinical trials have demonstrated an improvement in exercise capacity and reduction in angina episodes with ranolazine. MedChem Express HY-17401
      Sodium channel;Calcium Channel TargetMol T0207

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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