ChemSpider 2D Image | Otilonium bromide | C29H43BrN2O4

Otilonium bromide

  • Molecular FormulaC29H43BrN2O4
  • Average mass563.567 Da
  • Monoisotopic mass562.240601 Da
  • ChemSpider ID65077

More details:



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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

21HN3N72PV
247-457-4 [EINECS]
26095-59-0 [RN]
4325
Bromure de N,N-diéthyl-N-méthyl-2-[(4-{[2-(octyloxy)benzoyl]amino}benzoyl)oxy]éthanaminium [French] [ACD/IUPAC Name]
Bromure d'otilonium [French] [INN]
Bromuro de otilonio [Spanish] [INN]
Doralin
Ethanaminium, N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-, bromide (1:1) [ACD/Index Name]
N,N-Diethyl-N-methyl-2-[(4-{[2-(octyloxy)benzoyl]amino}benzoyl)oxy]ethanaminium bromide [ACD/IUPAC Name]
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Target Organs:

      Calcium Channel inhibitor;AChR antagonist TargetMol T1474
    • Bio Activity:

      Calcium Channel;Muscarinic AChR TargetMol T1474
      GPCR/G protein MedChem Express HY-B0499A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0499A
      mAChR MedChem Express HY-B0499A
      Membrane Transporter/Ion Channel; Neuroscience TargetMol T1474
      Otilonium Bromide is an antimuscarinic used as a spasmolytic agent. MedChem Express
      Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.; Target: mAChR; Otilonium bromide inhibited the generation of ACh-induced calcium signals in a dose dependent manner (IC50=880 nM) [1]. MedChem Express HY-B0499A
      Otilonium Bromide is an antimuscarinic used as a spasmolytic agent.;Target: mAChROtilonium bromide inhibited the generation of ACh-induced calcium signals in a dose dependent manner (IC50=880 nM) [1]. Otilonium, a clinically useful spasmolytic, behaves as a potent blocker of neuronal nicotinic acetylcholine receptors (AChR). Whole-cell Ba2+ currents (IBa) through Ca2+ channels of voltage-clamped chromaffin cells were blocked by otilonium with an IC50 of 6.4 microM. Otilonium inhibited the secretory responses induced by 10 s pulses of 50 microM DMPP with an IC50 of 7.4 nM [2]. Otilonium bromide may represent an effective treatment for irritable bowel syndrome because it reduces its predominant symptom (abdominal pain/ discomfort) more than placebo does [3]. ilonium bromide (OB) is a spasmolytic agent that blocks L-Type Calcium channels in human colonic smooth muscle. otilonium bromide is safe, well tolerated and superior to placebo in reducing the frequency of abdominal pain, severi MedChem Express HY-B0499A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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