ChemSpider 2D Image | SU11274 | C28H30ClN5O4S

SU11274

  • Molecular FormulaC28H30ClN5O4S
  • Average mass568.087 Da
  • Monoisotopic mass567.170715 Da
  • ChemSpider ID7828213

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)
(3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-5-indolinesulfonamide [ACD/IUPAC Name]
(3Z)-N-(3-Chlorophényl)-3-({3,5-diméthyl-4-[(4-méthyl-1-pipérazinyl)carbonyl]-1H-pyrrol-2-yl}méthylène)-N-méthyl-2-oxo-5-indolinesulfonamide [French] [ACD/IUPAC Name]
(3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
(3Z)-N-(3-chlorophenyl)-3-{[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene}-N-methyl-2-oxo-1H-indole-5-sulfonamide
(3Z)-N-(3-chlorophenyl)-3-{[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene}-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
(3Z)-N-(3-Chlorphenyl)-3-({3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl}methylen)-N-methyl-2-oxo-5-indolinsulfonamid [German] [ACD/IUPAC Name]
1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)- [ACD/Index Name]
658084-23-2 [RN]
MFCD08276928 [MDL number]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

S9820_SIGMA [DBID]
SU-011274 [DBID]
SU-11274 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Enzyme-Linked Receptors Tocris Bioscience 4101
      MET Receptors Tocris Bioscience 4101
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 4101
      Selective inhibitor of MET kinase activity Tocris Bioscience 4101
      Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 ?M in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migr ation in vitro and tumor angiogenesis in vivo. Tocris Bioscience 4101
      Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 ?M in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo. Tocris Bioscience 4101
      Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 muM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo. Tocris Bioscience 4101

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.664
Molar Refractivity: 150.4±0.4 cm3
#H bond acceptors: 9
#H bond donors: 2
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 1
ACD/LogP: 2.15
ACD/LogD (pH 5.5): 1.38
ACD/BCF (pH 5.5): 3.16
ACD/KOC (pH 5.5): 33.35
ACD/LogD (pH 7.4): 2.60
ACD/BCF (pH 7.4): 53.01
ACD/KOC (pH 7.4): 559.38
Polar Surface Area: 114 Å2
Polarizability: 59.6±0.5 10-24cm3
Surface Tension: 63.3±3.0 dyne/cm
Molar Volume: 405.5±3.0 cm3

Click to predict properties on the Chemicalize site


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