ChemSpider 2D Image | LY333531 hydrochloride | C28H29ClN4O3

LY333531 hydrochloride

  • Molecular FormulaC28H29ClN4O3
  • Average mass505.008 Da
  • Monoisotopic mass504.192810 Da
  • ChemSpider ID8046476

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(18S)-18-[(Dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaen-3,5-dionhydrochlorid (1:1) [German] [ACD/IUPAC Name]
(18S)-18-[(Dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaene-3,5-dione hydrochloride (1:1) [ACD/IUPAC Name]
(18S)-18-[(Diméthylamino)méthyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8,10,12,22,24,26-nonaène-3,5-dione, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
169939-93-9 [RN]
9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione, 9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-, (9S)-, hydrochloride (1:1) [ACD/Index Name]
LY333531 (hydrochloride)
LY333531 hydrochloride
Ruboxistaurin hydrochloride
(9S)-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione, monohydrochloride
(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

6496V4OCZN [DBID]
LY 333531 [DBID]
LY-333531 [DBID]
UNII:6496V4OCZN [DBID]
UNII-6496V4OCZN [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB0393
      Enzymes Tocris Bioscience 4738
      Enzymes/Kinase/PKC Hello Bio HB0393
      Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKC?I and PKC?II (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKC? over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 ?M for PKC?, -?, -?, -?, -? and -? respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, cas ein kinase and src). Tocris Bioscience 4738
      Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKC?I and PKC?II (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKC? over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 ?M for PKC?, -?, -?, -?, -? and -? respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). Tocris Bioscience 4738
      Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCbetaI and PKCbetaII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCbeta over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 muM for PKCeta, -delta, -gamma, -alpha, -epsilon and -zeta respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). Tocris Bioscience 4738
      Kinases Tocris Bioscience 4738
      Potent, selective and competitive protein kinase C (PKC) inhibitor. Selective for PKC&beta;I and PKC&beta;II (IC<sub>50</sub> values are 4.7 and 5.9 nM respectively) over PKC&alpha; by 76- and 61- fold respectively. Shows antinociceptive actions against and improves vascular function in diabetes. Hello Bio HB0393
      Potent, selective, competitive PKC inhibitor Hello Bio HB0393
      Protein Kinase C Tocris Bioscience 4738
      Protein kinase C inhibitor; selective for ? isozymes Tocris Bioscience 4738
      Protein kinase C inhibitor; selective for beta isozymes Tocris Bioscience 4738

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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