ChemSpider 2D Image | Decanoyl-RVKR-CMK | C34H66ClN11O5

Decanoyl-RVKR-CMK

  • Molecular FormulaC34H66ClN11O5
  • Average mass744.411 Da
  • Monoisotopic mass743.493713 Da
  • ChemSpider ID8137680

  • defined stereocentres - 4 of 4 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

150113-99-8 [RN]
Decanoyl-RVKR-CMK
Furin Inhibitor I
L-Lysinamide, N5-(diaminomethylene)-N2-(1-oxodecyl)-L-ornithyl-L-valyl-N-[(1S)-1-(2-chloroacetyl)-4-[(diaminomethylene)amino]butyl]- [ACD/Index Name]
N2-Decanoyl-N5-(diaminomethylen)-L-ornithyl-L-valyl-N-{(3S)-1-chlor-6-[(diaminomethylen)amino]-2-oxo-3-hexanyl}-L-lysinamid [German] [ACD/IUPAC Name]
N2-Decanoyl-N5-(diaminomethylene)-L-ornithyl-L-valyl-N-{(3S)-1-chloro-6-[(diaminomethylene)amino]-2-oxo-3-hexanyl}-L-lysinamide [ACD/IUPAC Name]
N2-Decanoyl-N5-(diaminométhylène)-L-ornithyl-L-valyl-N-{(3S)-1-chloro-6-[(diaminométhylène)amino]-2-oxo-3-hexanyl}-L-lysinamide [French] [ACD/IUPAC Name]
[150113-99-8] [RN]
DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE
DEC-RVKR-CMK
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A tetrapeptide consisting of N-decanoyl-L-arginine, L-valine, L-lysine, and L-arginine joined in sequence by peptide linkages and in which the carboxy group at the C-terminus is substituted by a chlor oacetyl group. It is a furin inhibitor that has antiviral activity against Chikungunya virus, Zika virus and Japanese encephalitis virus. ChEBI CHEBI:156289

    • Bio Activity:

      Enzymes Tocris Bioscience 3501
      Other Proteases Tocris Bioscience 3501
      Proteases Tocris Bioscience 3501
      Subtilisin/Kex2p-like proprotein convertase inhibitor Tocris Bioscience 3501
      Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Tocris Bioscience 3501
      Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in PC12 cells. Tocris Bioscience 3501

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.585
Molar Refractivity: 195.5±0.5 cm3
#H bond acceptors: 16
#H bond donors: 14
#Freely Rotating Bonds: 30
#Rule of 5 Violations: 3
ACD/LogP: 3.38
ACD/LogD (pH 5.5): -2.89
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -2.84
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 288 Å2
Polarizability: 77.5±0.5 10-24cm3
Surface Tension: 50.6±7.0 dyne/cm
Molar Volume: 583.6±7.0 cm3

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