ChemSpider 2D Image | Vanoxerine hydrochloride | C28H34Cl2F2N2O

Vanoxerine hydrochloride

  • Molecular FormulaC28H34Cl2F2N2O
  • Average mass523.485 Da
  • Monoisotopic mass522.201599 Da
  • ChemSpider ID94684

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(2-[bis(4-Fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride [ACD/IUPAC Name]
1-{2-[Bis(4-fluorophényl)méthoxy]éthyl}-4-(3-phénylpropyl)pipérazine, dichlorhydrate [French] [ACD/IUPAC Name]
1-{2-[Bis(4-fluorphenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazindihydrochlorid [German] [ACD/IUPAC Name]
67469-78-7 [RN]
GBR 12909 (hydrochloride)
GBR 12909 dihydrochloride
MFCD00055193 [MDL number]
Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2) [ACD/Index Name]
Vanoxerine dihydrochloride
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CHEBI:64086 [DBID]
MWO1IP03EV [DBID]
D052_SIGMA [DBID]
EU-0100446 [DBID]
Gbr 12909 [DBID]
GBR-12909 [DBID]
I 893 [DBID]
I-893 [DBID]
Prestwick_664 [DBID]
UNII:MWO1IP03EV [DBID]
  • References
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      Soluble in water (25 mM, gentle warming) and in DMSO (50 mM) Hello Bio HB1812
      Soluble to 5 mM in water and to 50 mM in DMSO Tocris Bioscience 0421
      Soluble to 5 mM in water with gentle warming and to 50 mM in DMSO Tocris Bioscience 0421, 421
  • Miscellaneous

    • Chemical Class:

      A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopami ne uptake). Has <greaterthan/> 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC<smallsub>50</smallsub> = 48 nM). Centrally active following systemi c administration. ChEBI CHEBI:64086
      A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopami ne uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemi; c administration. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:64086
      A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopami ne uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. ChEBI CHEBI:64086

    • Bio Activity:

      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB1812
      Dopamine Transporters Tocris Bioscience 421
      Neurotransmitter Transporters Tocris Bioscience 421
      Potent, competitive dopamine uptake inhibitor Hello Bio HB1812
      Potent, competitive dopamine uptake inhibitor (K<sub>i</sub> = 1 nM). Also a potent K<sub>v</sub>11.1, and Na<sup>+</sup> and Ca<sup>+</sup> channel blocker (IC<sub>50</sub> values are 0.8, 320 and 830 nM at hK<sub>v</sub>11.1, hI<sub>Ca,L</sub> and hNa<sub>v</sub>1.5 respectively and &sigma; receptor blocker). Shows variety of biological actions. Active <em>in vivo</em>. Hello Bio HB1812
      Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigm a ligand (IC50 = 48 nM). Centrally active following systemic administration. Tocris Bioscience 0421
      Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. Tocris Bioscience 421
      Receptors & Transporters/Transporters/Dopamine (DAT) Hello Bio HB1812
      Selective DA uptake inhibitor. Also ? ligand Tocris Bioscience 0421, 421
      Selective DA uptake inhibitor. Also sigma ligand Tocris Bioscience 421
      Transporters Tocris Bioscience 421

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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