ChemSpider 2D Image | Aclidinium bromide | C26H30BrNO4S2

Aclidinium bromide

  • Molecular FormulaC26H30BrNO4S2
  • Average mass564.555 Da
  • Monoisotopic mass563.079956 Da
  • ChemSpider ID9694529

  • Charge - Charge

    defined stereocentres - 1 of 3 defined stereocentres

More details:

Featured data source
The Merck Index Online

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3R)-3-[2-Hydroxy(di-2-thienyl)acetoxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octanbromid [German] [ACD/IUPAC Name]
(3R)-3-[2-Hydroxy(di-2-thienyl)acetoxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide [ACD/IUPAC Name]
(3R)-3-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azabicyclo[2.2.2]octan-1-ium bromide
1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, bromide, (3R)- (1:1) [ACD/Index Name]
320345-99-1 [RN]
Aclidinium (Bromide)
Aclidinium bromide [USAN] [Wiki]
Bromure de (3R)-3-[2-hydroxy-2,2-di(2-thiényl)acétoxy]-1-(3-phénoxypropyl)-1-azoniabicyclo[2.2.2]octane [French] [ACD/IUPAC Name]
Tudorza Pressair
UQW7UF9N91
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

8544 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A quaternary ammonium salt that is the bromide salt of aclidinium. A muscarinic acetylcholine M<smallsub>3</smallsub> receptor antagonist, for the long-term maintenance treatment of bronchospasm assoc iated with chronic obstructive pulmonary disease (COPD). ChEBI CHEBI:65344
      A quaternary ammonium salt that is the bromide salt of aclidinium. A muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment of bronchospasm associated with chronic ob structive pulmonary disease (COPD). ChEBI CHEBI:65344

    • Bio Activity:

      Aclidinium Bromide(LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist as a maintenance treatment for chronic obstructive pulmonary disease (COPD). MedChem Express http://www.medchemexpress.com/Cisapride.html, HY-14144
      Aclidinium Bromide(LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist as a maintenance treatment for chronic obstructive pulmonary disease (COPD). ;IC50 value:;Target: M3 receptorPreclinically, aclidinium showed potent antagonism of human muscarinic receptors, with a long residence time at M3 receptors and a shorter residence time at M2 receptors, indicating the potential to provide sustained bronchodilation. Aclidinium is rapidly hydrolysed in human plasma, unlike other currently available antimuscarinics including tiotropium. Early clinical studies in healthy subjects have confirmed the low systemic bioavailability and favourable safety profile of single and multiple doses of aclidinium. In a subsequent Phase IIb study, which included 464 patients with moderate to severe COPD, aclidinium displayed long-lasting bronchodilatory activity and was well tolerated. MedChem Express HY-14144
      GPCR/G protein MedChem Express HY-14144
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-14144
      mAChR MedChem Express HY-14144

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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