ChemSpider 2D Image | APILIMOD MESYLATE | C25H34N6O8S2

APILIMOD MESYLATE

  • Molecular FormulaC25H34N6O8S2
  • Average mass610.703 Da
  • Monoisotopic mass610.187927 Da
  • ChemSpider ID9702116

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

4-{6-[(1E,2E)-2-(3-Methylbenzylidene)hydrazino]-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl}morpholine methanesulfonate (1:2) [ACD/IUPAC Name]
870087-36-8 [RN]
Acide méthanesulfonique - 4-{6-[(1E,2E)-2-(3-méthylbenzylidène)hydrazino]-2-[2-(2-pyridinyl)éthoxy]-4-pyrimidinyl}morpholine (2:1) [French] [ACD/IUPAC Name]
APILIMOD MESYLATE
Benzaldehyde, 3-methyl-, 2-[(4E)-6-(4-morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4(1H)-pyrimidinylidene]hydrazone, methanesulfonate (1:2) [ACD/Index Name]
Methansulfonsäure --4-{6-[(1E,2E)-2-(3-methylbenzyliden)hydrazino]-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl}morpholin (2:1) [German] [ACD/IUPAC Name]
(E)-4-(6-(2-(3-METHYLBENZYLIDENE)HYDRAZINYL)-2-(2-(PYRIDIN-2-YL)ETHOXY)PYRIMIDIN-4-YL)MORPHOLINE DIMETHANESULFONATE
[(3-methylbenzylidene)amino]-[6-morpholino-2-[2-(2-pyridyl)ethoxy]pyrimidin-4-yl]amine
[870087-36-8] [RN]
4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dimethanesulfonate
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

5G3P5OK11S [DBID]
UNII:5G3P5OK11S [DBID]
UNII-5G3P5OK11S [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS?stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.; IC50 value: 10 nM (IFN-/LPS?stimulated human PBMCs) [1]; Target: IL-12/IL-23; in vitro: STA-5326 not only inhibited IL-12, but it also potently inhibited IL-23 and total p40 products in various forms as monomer, homodimer, and heterodimerin IFN-/SAC?stimulated human PBMCs [1]. MedChem Express HY-14644A
      Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS?stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.;IC50 value: 10 nM (IFN-/LPS?stimulated human PBMCs) [1];Target: IL-12/IL-23;In vitro: STA-5326 not only inhibited IL-12, but it also potently inhibited IL-23 and total p40 products in various forms as monomer, homodimer, and heterodimerin IFN-/SAC?stimulated human PBMCs [1]. STA-5326 inhibited IFN-r production induced by either IFN-/SAC or SAC in human PBMCs, with an IC50 of approximately 20 nM, while the compound had no significant effect on the production when T cells were stimulated using anti-CD3 and anti-CD28 antibodies, suggesting that the T-cell?receptor?dependent production of IFN- that occurs independently of suppression of Th1 cells via inhibition of IL-12 is not directly inhibited by the compound [1].;In vivo: Patients with CD responded within 14 days of treatment with apilimod and, a MedChem Express HY-14644A
      Immunology/Inflammation MedChem Express HY-14644A
      Immunology/Inflammation; MedChem Express HY-14644A
      Interleukin Related MedChem Express HY-14644A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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