ChemSpider 2D Image | Pitolisant hydrochloride | C17H27Cl2NO

Pitolisant hydrochloride

  • Molecular FormulaC17H27Cl2NO
  • Average mass332.308 Da
  • Monoisotopic mass331.146973 Da
  • ChemSpider ID9726467

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Pitolisant hydrochloride
1-{3-[3-(4-CHLOROPHENYL)PROPOXY]PROPYL}PIPERIDINE HYDROCHLORIDE
1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine hydrochloride (1:1) [ACD/IUPAC Name]
1-{3-[3-(4-Chlorophényl)propoxy]propyl}pipéridine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
1-{3-[3-(4-Chlorphenyl)propoxy]propyl}piperidinhydrochlorid (1:1) [German] [ACD/IUPAC Name]
903576-44-3 [RN]
BF 2649
BF 2649 hydrochloride
Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-, hydrochloride (1:1) [ACD/Index Name]
Pitolisant [INN] [Wiki]
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 3743
      GPCR/G protein MedChem Express HY-12199B
      GPCR/G protein; MedChem Express HY-12199B
      H3 receptor inverse agonist/antagonist Tocris Bioscience 3743
      Histamine H3 receptor inverse agonist (EC50 = 1.5 nM) and antagonist (Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brai n penetrant. Tocris Bioscience 3743
      Histamine H3 receptor inverse agonist (EC50 = 1.5 nM) and antagonist (Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant. Tocris Bioscience 3743
      Histamine H3 Receptors Tocris Bioscience 3743
      Histamine Receptor MedChem Express HY-12199B
      Histamine Receptors Tocris Bioscience 3743
      Pitolisant Hcl(BF2.649;Ciproxidine ) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM). MedChem Express
      Pitolisant Hcl(BF2.649;Ciproxidine ) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM).; IC50 Value: 0.16 nM (Ki value); 1.5 nM (EC50) [1]; Target: H3 receptor; BF2.649 behaved as a competitive antagonist with a Ki value of 0.16 nM and as an inverse agonist with an EC50 value of 1.5 nM and an intrinsic activity approximately 50% higher than that of ciproxifan.; in vitro: BF2.649 behaved as a competitive antagonist with a Ki value of 0.16 nM and as an inverse agonist with an EC50 value of 1.5 nM and an intrinsic activity approximately 50% higher than that of ciproxifan. MedChem Express HY-12199B
      Pitolisant Hcl(BF2.649;Ciproxidine ) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM).;IC50 Value: 0.16 nM (Ki value); 1.5 nM (EC50) [1];Target: H3 receptorBF2.649 behaved as a competitive antagonist with a Ki value of 0.16 nM and as an inverse agonist with an EC50 value of 1.5 nM and an intrinsic activity approximately 50% higher than that of ciproxifan.;In vitro: BF2.649 behaved as a competitive antagonist with a Ki value of 0.16 nM and as an inverse agonist with an EC50 value of 1.5 nM and an intrinsic activity approximately 50% higher than that of ciproxifan. Pitolisant in vitro potency was approximately 6 times lower at the rodent receptor [1].;In vivo: In mice, the oral bioavailability coefficient, i.e., the ratio of plasma areas under the curve after oral and i.v. administrations, respectively, was 84%. BF2.649 dose dependently enhanced tele-methylhistamine levels in mouse brain, an index of histaminergic ne MedChem Express HY-12199B
      Potent and selective H3 receptor inverse agonist Tocris Bioscience 3743
      Potent and selective histamine H3 receptor inverse agonist (EC50 = 1.5 nM, Ki = 0.16 nM). Exhibits nootropic effects in cognitive disorders; reduces locomotor hyperactivity induced by methamphetamine. Brain penetrant. Tocris Bioscience 3743

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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