ChemSpider 2D Image | RAF265 | C24H16F6N6O


  • Molecular FormulaC24H16F6N6O
  • Average mass518.414 Da
  • Monoisotopic mass518.128967 Da
  • ChemSpider ID9831256

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1H-Benzimidazol-2-amine, 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]- [ACD/Index Name]
1-Methyl-5-({2-[4-(trifluormethyl)-1H-imidazol-2-yl]-4-pyridinyl}oxy)-N-[4-(trifluormethyl)phenyl]-1H-benzimidazol-2-amin [German] [ACD/IUPAC Name]
1-Methyl-5-({2-[4-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine [ACD/IUPAC Name]
1-Méthyl-5-({2-[4-(trifluorométhyl)-1H-imidazol-2-yl]-4-pyridinyl}oxy)-N-[4-(trifluorométhyl)phényl]-1H-benzimidazol-2-amine [French] [ACD/IUPAC Name]
927880-90-8 [RN]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Enzymes Tocris Bioscience 6015
      Kinases Tocris Bioscience 6015
      MAPK MedChem Express HY-10248
      MAPK; Protein Tyrosine Kinase/RTK; MedChem Express HY-10248
      Raf MedChem Express HY-10248
      Raf Kinase Tocris Bioscience 6015
      Raf kinase and VEGFR-2 inhibitor Tocris Bioscience 6015
      Raf kinase and VEGFR-2 inhibitor. Inhibits c-Raf, wild type B-Raf and mutant B-Raf (V600E). Cytotoxic in certain melanoma cells lines. Effects enhanced by protein kinase D3 inhibition, preventing reactivation of MAPK signaling and increasing caspase activity. Orally bioavailable. Tocris Bioscience 6015
      Raf VEGFR MedChem Express HY-10248
      RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM.; IC50 value: 3-60 nM (B-Raf); 30 nM(EC50 for VEGFR2) [1]; Target: B-Raf; VEGFR2; B-Raf V600E; in vitro: RAF265 inhibits C-Raf, wild type B-Raf and mutant (V600E) B-Raf. MedChem Express HY-10248

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 667.6±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.0 mmHg at 25°C
Enthalpy of Vaporization: 98.1±3.0 kJ/mol
Flash Point: 357.5±34.3 °C
Index of Refraction: 1.622
Molar Refractivity: 121.1±0.5 cm3
#H bond acceptors: 7
#H bond donors: 2
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 2
ACD/LogP: 6.03
ACD/LogD (pH 5.5): 5.12
ACD/BCF (pH 5.5): 4011.56
ACD/KOC (pH 5.5): 11235.00
ACD/LogD (pH 7.4): 5.34
ACD/BCF (pH 7.4): 6694.47
ACD/KOC (pH 7.4): 18748.91
Polar Surface Area: 81 Å2
Polarizability: 48.0±0.5 10-24cm3
Surface Tension: 43.4±7.0 dyne/cm
Molar Volume: 343.9±7.0 cm3

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