ChemSpider 2D Image | Pf-00562271 Free Base | C21H20F3N7O3S

Pf-00562271 Free Base

  • Molecular FormulaC21H20F3N7O3S
  • Average mass507.489 Da
  • Monoisotopic mass507.130035 Da
  • ChemSpider ID9887880

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

717907-75-0 [RN]
Methanesulfonamide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl- [ACD/Index Name]
N-methyl-N-(3-((2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino)-methyl)-pyridin-2-yl)-methanesulfonamide
N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]methanesulfonamide
N-Methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluormethyl)-4-pyrimidinyl}amino)methyl]-2-pyridinyl}methansulfonamid [German] [ACD/IUPAC Name]
N-Methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl}amino)methyl]-2-pyridinyl}methanesulfonamide [ACD/IUPAC Name]
N-Méthyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluorométhyl)-4-pyrimidinyl}amino)méthyl]-2-pyridinyl}méthanesulfonamide [French] [ACD/IUPAC Name]
Pf-00562271 Free Base
PF-562,271
(2-Fluoro-4-trifluoromethyl-phenyl)-acetic acid
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

K5BX8ZA7UF [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      FAK inhibitor TargetMol T2465

    • Bio Activity:

      Angiogenesis TargetMol T2465
      FAK MedChem Express HY-10459
      FAK;PYK2;CDK2/CDK3/CDK1/CDK7 TargetMol T2465
      PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and MedChem Express http://www.medchemexpress.com/PF-573228.html
      PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.; IC50 value: 1.5 nM(FAK); 14 nM(Pyk2) [1]; Target: PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three ?canonical? H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. MedChem Express HY-10459
      Protein Tyrosine Kinase/RTK MedChem Express HY-10459
      Protein Tyrosine Kinase/RTK; MedChem Express HY-10459

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.645
Molar Refractivity: 119.4±0.4 cm3
#H bond acceptors: 10
#H bond donors: 3
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 2
ACD/LogP: -0.71
ACD/LogD (pH 5.5): 1.75
ACD/BCF (pH 5.5): 12.49
ACD/KOC (pH 5.5): 211.01
ACD/LogD (pH 7.4): 1.75
ACD/BCF (pH 7.4): 12.70
ACD/KOC (pH 7.4): 214.62
Polar Surface Area: 138 Å2
Polarizability: 47.3±0.5 10-24cm3
Surface Tension: 72.0±3.0 dyne/cm
Molar Volume: 329.5±3.0 cm3

Click to predict properties on the Chemicalize site


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