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Search term: 171436-38-7 (Found by approved synonym)
ChemSpider 2D Image | PAR2-AP | C29H56N10O7

PAR2-AP

  • Molecular FormulaC29H56N10O7
  • Average mass656.818 Da
  • Monoisotopic mass656.433350 Da
  • ChemSpider ID8006784

  • defined stereocentres - 6 of 6 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2S,3S)-2-[(2S)-2-[(2S)-2-amino-3-hydroxypropanamido]-4-methylpentanamido]-N-({[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoyl-3-methylbutyl]carbamoyl}butyl]carbamoyl}methyl)-3-methylpentanamide
171436-38-7 [RN]
L-Leucinamide, L-seryl-L-leucyl-L-isoleucylglycyl-N5-(diaminomethylene)-L-ornithyl- [ACD/Index Name]
L-Seryl-L-leucyl-L-isoleucylglycyl-N5-(diaminomethylen)-L-ornithyl-L-leucinamid [German] [ACD/IUPAC Name]
L-Seryl-L-leucyl-L-isoleucylglycyl-N5-(diaminomethylene)-L-ornithyl-L-leucinamide [ACD/IUPAC Name]
L-Séryl-L-leucyl-L-isoleucylglycyl-N5-(diaminométhylène)-L-ornithyl-L-leucinamide [French] [ACD/IUPAC Name]
MFCD03093421
PAR2-AP
SLIGRL-NH
SLIGRL-NH2
More...
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      <p><span style="text-decoration: underline;"><strong>Overview</strong></span></p> <p><span style="text-decoration: underline;"><strong></strong></span>SLIGRL-NH2 is a PAR<sub>2</sub> peptide agonist which is specific for activation of PAR<sub>2</sub> over PAR<sub>1</sub> and PAR<sub>4</sub> (EC<sub>50</sub> = 0.5-2.0&micro;M).</p> <p style="margin-bottom: 2em;">The peptide is derived from the N-terminus of the rat PAR<sub>2</sub> receptor sequence.</p> <p><span style="text-decoration: underline;"><strong>Uses</strong></span></p> <p>SLIGRL-NH2 is an itch-inducing agent which is commonly used to study histamine-independent itch. It evokes dose dependent scratching behaviour in mice. Interestingly, in pruritogen-responsive neurons that transmit the itch signal induced by SLIGRL-NH2, sex-related differences may exist.</p> <p>The peptide has also been shown to enhance gastrointestinal transit in mice and rats</p> <p>Active <em>in vivo</em>.</p> Hello Bio HB2920
      <p><span style=text-decoration: underline;><strong>Overview</strong></span></p> <p><span style=text-decoration: underline;><strong></strong></span>SLIGRL-NH2 is a PAR<sub>2</sub> peptide agonist which is specific for activation of PAR<sub>2</sub> over PAR<sub>1</sub> and PAR<sub>4</sub> (EC<sub>50</sub> = 0.5-2.0&micro;M).</p> <p style=margin-bottom: 2em;>The peptide is derived from the N-terminus of the rat PAR<sub>2</sub> receptor sequence.</p> <p><span style=text-decoration: underline;><strong>Uses</strong></span></p> <p>SLIGRL-NH2 is an itch-inducing agent which is commonly used to study histamine-independent itch. It evokes dose dependent scratching behaviour in mice. Interestingly, in pruritogen-responsive neurons that transmit the itch signal induced by SLIGRL-NH2, sex-related differences may exist.</p> <p>The peptide has also been shown to enhance gastrointestinal transit in mice and rats</p> <p>Active <em>in vivo</em>.</p> Hello Bio HB2920
      7-TM Receptors Tocris Bioscience 1468
      Agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 ?M) and facilitates gastrointestinal transit in mice in vivo. Control peptide LRGILS-NH2 ( Cat. No. 3394) also available. Tocris Bioscience 1468
      Agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 ?M) and facilitates gastrointestinal transit in mice in vivo. Control peptide LRGILS-NH2 (Cat. No. 3394) also available. Tocris Bioscience 1468
      Agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 muM) and facilitates gastrointestinal transit in mice in vivo. Control Peptide also available. Tocris Bioscience 1468
      Agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 muM) and facilitates gastrointestinal transit in mice in vivo. Control peptide LRGILS-NH2 (Cat. No. 3394) also available. Tocris Bioscience 1468
      PAR<sub>2</sub> peptide agonist Hello Bio HB2920
      PAR2-activating peptide Tocris Bioscience 1468
      Peptide Receptors Tocris Bioscience 1468
      Protease-Activated Receptors Tocris Bioscience 1468
      Proteins & peptides Hello Bio HB2920
      Receptors & Transporters/Peptide Receptors/Protease-Activated Receptors (PAR) Hello Bio HB2920

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.598
Molar Refractivity: 167.0±0.5 cm3
#H bond acceptors: 17
#H bond donors: 14
#Freely Rotating Bonds: 22
#Rule of 5 Violations: 3
ACD/LogP: -0.29
ACD/LogD (pH 5.5): -4.74
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -3.68
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 299 Å2
Polarizability: 66.2±0.5 10-24cm3
Surface Tension: 52.3±7.0 dyne/cm
Molar Volume: 489.4±7.0 cm3

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