Found 1 result

Search term: 366-70-1 (Found by approved synonym)
ChemSpider 2D Image | Procarbazine hydrochloride | C12H20ClN3O

Procarbazine hydrochloride

  • Molecular FormulaC12H20ClN3O
  • Average mass257.760 Da
  • Monoisotopic mass257.129486 Da
  • ChemSpider ID9322

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

206-678-6 [EINECS]
366-70-1 [RN]
4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide hydrochloride
4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide hydrochloride (1:1)
benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride
Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-, hydrochloride (1:1) [ACD/Index Name]
MFCD00072082 [MDL number]
N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride
N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide hydrochloride (1:1) [ACD/IUPAC Name]
N-Isopropyl-4-[(2-méthylhydrazino)méthyl]benzamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

XH0NPH5ZX8 [DBID]
AI3-50844 [DBID]
AIDS027551 [DBID]
AIDS-027551 [DBID]
CCRIS 531 [DBID]
D00478 [DBID]
NCI-C01810 [DBID]
NSC 77213 [DBID]
NSC77213 [DBID]
NSC-77213 [DBID]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      DNA Synthesis inhibitor TargetMol T1488

    • Chemical Class:

      A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarb azine and hydrogen peroxide, which results in the breaking of DNA strands. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:71428, CHEBI:71428

    • Therapeutical Effect:

      Antineoplastic Agents Sean Ekins

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-13733
      Cell Cycle/DNA Damage; MedChem Express HY-13733
      DNA TargetMol T1488
      DNA alkylator/crosslinker MedChem Express HY-13733
      DNA Damage/DNA Repair TargetMol T1488
      Procarbazine Hcl, an antineoplastic chemotherapy drug, is an alkylating agent for the treatment of Hodgkin's lymphoma and certain brain cancers; also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.; Target: DNA alkylating agent; MAO; The mechanism of action is not fully understood. MedChem Express HY-13733
      Procarbazine Hcl, an antineoplastic chemotherapy drug, is an alkylating agent for the treatment of Hodgkin's lymphoma and certain brain cancers; also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.;Target: DNA alkylating agent; MAO;The mechanism of action is not fully understood. Metabolism yields azo-procarbazine and hydrogen peroxide which results in the breaking of DNA strands.Exposure to procarbazine hydrochloride by intraperitoneal injection caused tumors in rats and mice at several different tissue sites. ;In both rats and mice, it caused cancer of the brain (olfactory neuroblastoma) and hematopoietic system (lymphoma in rats and lymphoma or leukemia in mice). In rats, it also caused mammary-gland cancer (adenocarcinoma) in both sexes. In mice, it also caused benign lung tumors (adenoma) in both sexes and uterine cancer (adenocarcinoma) in females [1] [2].Procarbazine hydrochloride is an oral alkylating agent primarily used as a component o MedChem Express HY-13733

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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